肾移植术后排斥反应与巨细胞病毒感染有关  

CYTOMEGALOVIRUS INFECTION IS RELATED TO THE REJECTION IN RENAL ALLOGRAFT RECIPIENTS

作　　者：张泓[1] 武大林[1] 吴涛[1] 籍会彩[1] 

机构地区：[1]第一军医大学附属南方医院外科实验室,广州510515

出　　处：《中国现代医学杂志》2002年第2期21-22,共2页China Journal of Modern Medicine

摘　　要：目的 :探讨巨细胞病毒 (CMV)感染在肾移植术后的发生率及CMV感染与排斥反应的关系。方法 :检测2 0 8例肾移植受者术后CMVDNA和 48例肾移植受者血清CMVIgM、IgG抗体。并定期复查CMVDNA ,对CMVDNA阳性的患者给予抗病毒治疗。结果 :术后CMVDNA阳性受者急性排斥反应的发生率增加 ,经抗CMV治疗 ,则排斥反应减少。结论Objective:To investigate the incidence of cytomegalovirus (CMV) infection in renal allograft recipients and the impact of CMV infection on rejection.Methods:207 renal allograft recipients were subjected to the PCR for CMV DNA after transplantation,48 recipients were subjected to the serum test for CMV- antibody IgM and IgG. CMV-DNA in recipients were detected in certain time. The patients with positive CMV DNA were given anti-CMV treatment.Results:CMV DNA(+) in recipients after operation enhanced the development of rejection. Ganciclovir therapy reduced the incidence of rejection.Conclusion:It is important to prevent and treat CMV infection in renal allograft recipients.

关 键 词：巨细胞病毒感染 肾移植 移植物排斥 

分 类 号：R699.2[医药卫生—泌尿科学] R373.11[医药卫生—外科学]