扩张型心肌病与β_1受体自身抗体关系初探  

A preliminary study on the relationship between the autoantibody against myocardial β_1 receptor and patients with dilated cardiomyopathy

作　　者：赵树进[1] 任京力[2] 杨太成[1] 

机构地区：[1]广州军区广州总医院,广州510010 [2]中山大学中山医学院药理教研室,广州510089

出　　处：《广东医学》2002年第3期236-237,共2页Guangdong Medical Journal

基　　金：全军医疗卫生科研基金资助 (编号 :98M0 37)

摘　　要：目的　探讨抗 β1受体自身抗体与扩张型心肌病 (DCM)之间的关系。方法　以人心脏 β1受体细胞外第二环表位肽段作为抗原 ,应用酶联免疫吸附测定 (ELISA)技术 ,检测 2 8例DCM患者和 3 2例正常人血清中 β1受体的自身抗体。结果　DCM患者血清中有 13例 (4 6% )抗 β1受体自身抗体阳性 ,正常人血清中有 2例 (6% ) ,两组阳性率差异有显著性 (P <0 .0 1) ;DCM组自身抗体平均几何滴度为 1:92 ,显著高于正常对照组 1:2 0 (P <0 .0 1) ;DCM患者中自身抗体阳性者的抗体滴度在不同心功能间的分布差异有显著性 (P <0 .0 0 1)。结论　DCM患者存在着Objective To determine whether the autoantibodies against β 1 adrenergic receptors are related to dilated cardiomyopathy (DCM). Method Synthetic peptide corresponding to amino acid squence (197-222) of the second extracelluar loop of the β 1 adrenergic receptor was used as antigen to screen sera from patients with DCM( n =28) and healthy blood donors (NC, n =32) as control. Results By ELISA, the positive rate of autobodies in DCM group was 46.4%(13 cases), significantly higher ( P <0.01) than that in control group(6.3%, 2 cases); the titer of autoantibody in DCM group was 1:92,also significantly higher ( P <0.01) than that in control group(1:20); and for the autoantibody-positive patients with DCM, the titer was significantly different among different heart function levels. Conclusion These findings indicated that autoantibody is present in patients with DCM with high titer than normal control. [

关 键 词：肾上腺素能 自身抗体 扩张型心肌病 心功能 

分 类 号：R542.2[医药卫生—心血管疾病]