少年儿童肺通气功能正常值与预计方程式  

Reference values and predicted equations of lung function in southern Chinese children

作　　者：郑劲平[1] 李敏然[1] 安嘉颖[1] 罗定芬[1] 刘妙芳[1] 

机构地区：[1]广州呼吸疾病研究所肺功能室,广州医学院附属第一医院510120

出　　处：《中华儿科杂志》2002年第2期103-106,共4页Chinese Journal of Pediatrics

基　　金：广东省卫生厅医药卫生科技项目 (A19972 41)

摘　　要：目的　建立儿童常规用力肺功能的正常参考值 ,并探讨儿童用力肺功能的特点。方法对广州地区 6～ 14岁正常儿童 385名 (男 2 0 0名 ,女 185名 ) ,采用美国Gould公司生产的 2 80 0型肺量计 ,参考美国胸科协会标准测定用力肺活量 (FVC)、1s用力呼气容积 (FEV1)、1s用力呼气容积占用力肺活量比值 (FEV1/FVC)等 13个指标 ,并对各实测指标作多元逐步线性回归及曲线回归 ,得出预计方程式。比较本方程与国内外常用预计值对指定身高、体重、年龄的儿童的差异。结果　FVC在各年龄组间差异有显著意义 (F(男 ) =4.5 6 2 ,F(女 ) =5 .137,P均 <0 .0 1) ;肺功能指标与身高、体重和年龄均呈密切正相关 ,但大多数肺功能指标与身高的关系最为密切 (如FEV1,男 =0 14145 3×身高0 0 193 8,r =0 93178,女 =0 12 70 97×身高0 0 19676,r=0 90 382 ,P均 <0 0 0 1)。儿童平均呼气时间 3.11s。建立了各肺功能指标的多元回归方程。结论　肺功能指标受身高变化影响大于体重和年龄变化 ;建立并推荐华南地区使用本儿童肺功能正常预计值。Pulmonary function testing (PFT) has become an integral part of the clinical assessment of pulmonary diseases and has been practiced more and more in pediatrics. The results of tests cannot be interpreted appropriately without reference values. It is recommended that laboratories should use the predicted equations that are most close to their population. However, there are no such references available for southern Chinese children until now. Objective This study was undertaken to characterize the forced expiratory maneuver of growth and establish the normal lung function prediction equations for southern Chinese children. Methods A survey in 385 healthy school children (200 boys, 185 girls) aged 6 to 14 years old was carried out in Guangzhou in 1998. Thirteen flow-volume tests parameters [e.g. forced vital capacity (FVC), forced expiratory volume at one second (FEV 1), maximal mid-expiratory flow rate (FEF 25%-75% )] were measured by using Gould 2800 spirometry. Stepwise multiple regressions and non-linear regressions were carried out with the statistical software SPSS 9.0 for Windows to identify the best predictors of lung function parameters using standing height, weight, age and gender as potential determinants. Standing height, weight and age were used to compare the predicted values from our equations and other commonly used equations such as Ploger′s, Knudson′s and Hong′s. Results All lung volumes and flow rates increased with the age, height as well as weight growth in both gender groups. FVC were significantly different among age groups in both genders (F boy =4.562, F girl =5.137, P all <0.001). It was found that lung volumes were higher in boys than those in girls under the age of 10 years, and cross-over occurred at the age of 11 to 12 years, then inversed again after 13 years of age. The correlation among most lung function parameters was higher in height than weight and age. The regression equation for FEV 1 and height is as follows:(Boys)FEV 1=0.141453×height 0.01913

关 键 词：肺通气 肺活量 儿童 参考值 预计方程式 

分 类 号：R448[医药卫生—诊断学]