β-七叶皂甙钠联合甘露醇治疗早期筋膜间室综合征  

Treatment of Reparil Combined with Mannitol on Early Compartment Syndrome

作　　者：王森林[1] 陈君[1] 徐新华[1] 郑季南[1] 

机构地区：[1]中国人民解放军第180医院,泉州362000

出　　处：《海峡药学》2002年第1期35-37,共3页Strait Pharmaceutical Journal

摘　　要：目的　观察β-七叶皂甙钠与小剂量甘露醇合用治疗筋膜间室综合征 (CS)的临床疗效。 方法 　临床确诊为筋膜间隙综合征 85例随机分为治疗组 43例予β-七叶皂甙钠 (2 0 mg· d- 1 )与小剂量甘露醇 (5 0～ 75 mg· d- 1 )静滴 ;对照组单纯予甘露醇 (10 0～ 2 0 0 mg· d- 1 )静滴 ,治疗 3周观察疗效。结果　治疗组显效率 5 3 .49% ;对照组显效率 40 .48%。两组疗效统计学分析有显著差异性 (P<0 .0 1)。结论 　β-七皂甙钠与小剂量甘露醇合用治疗筋膜间室综合征疗效显著 。OBJECTIVE To investigate the effect of reparil combined with mannitol on patients with early compartment syndrome(CS).METHODS 85 cases diagnosed as CS were randomly divided into two groups:treating group(43)with intravenous drip of reparil(20mg·d -1 )and mannitol while control group(42)with intravenous drip of only mannitol(100～200mg·d -1 ).Three weeks later the results were observed.RESULTS In the treating group,the effective rate was 5349%,and the total effective rate was 8837%,while in the control group the the effective rate was 4048%,and the total effective rate was 6667%,the statistical analysis of which was significantly differdnt(P<001).CONCLUSION In the treatment of early CS,reparil combined with minor dose of mannitol is more effective than only mannitol.

关 键 词：Β-七叶皂甙钠 甘露醇 筋膜间室综合征 药物疗法 作用机制 

分 类 号：R651[医药卫生—外科学] R977[医药卫生—临床医学]