冠状动脉血管内视镜对无症状性斑块破裂的观察及其与冠心病危险因子关系的探讨  

Evaluation of the relationship between asymptomatic plaque rupture and coronary heart disease risk factors by coronary angioscopy

作　　者：马淑梅[1] 李晓东[1] 孙亚清[1] 王丽君[1] 水野杏一[2] 大场崇芳 

机构地区：[1]中国医科大学第二临床学院心内科,沈阳110004 [2]日本医科大学附属千叶北总病院

出　　处：《中华心血管病杂志》2002年第2期90-92,共3页Chinese Journal of Cardiology

摘　　要：目的　通过对无症状性冠状动脉粥样斑块的观察及其与各种冠心病危险因子关系的探讨 ,为临床上预防急性冠状动脉综合征的发生提供积极的防治措施。方法　应用冠状动脉血管内视镜连续观察 62例冠心病患者的非罪犯血管内粥样斑块的颜色及有无破裂发生 ,探讨其与冠心病危险因子之间的关系。结果　非罪犯血管内观察到黄色斑块者 48例 (77 4% ) ,其中合并高胆固醇血症者39例 (81 3 % ) ,与 1 4例无黄色斑块组中的 6例 (42 9% )相比 ,差异有显著性意义 (P <0 0 5)。非罪犯血管内观察到斑块破裂者 31例 (50 0 % ) ,其中合并高血压者 2 3例 (74 2 % ) ,与 31例无斑块破裂组中的 1 0例 (32 3 % )相比 ,差异有显著性意义 (P <0 0 5)。结论　胆固醇的增加与黄色斑块的形成有关 。Objective To evaluate the correlation between the asymptomatic plaque rupture and the risk of acute coronary heart disease through investigation of asymptomatic plaque rupture Methods The color of plaque in the non responsible vessels and the incidences of the plaque rupture were investigated by angioscopy in 62 patients with coronary heart disease The relationship between asymptomatic plaque rupture and smoking, hypertension, hyperlipemia, hyperuricemia and family histories were analysed Results Yellow plaque was detected in non responsible vessels(77 4%) Among them, 39(81 3%) were accompanied by hypercholesterolemia, compared with 6(42 9%)in the non yellow plaque group( n =14) There were significant differences Plaque rupture was detected in non responsible vessels of 31 patients(50%) Among them, 74 2% were accompanied by hypertension(32 3%) in none plaque rupture There were significant differences in the incidence of plaque rupture between groups Conclusions Cholesterol is the fundamental substance of asymptomatic plaque Hypertension is one of the triger factors of plaque rupture

关 键 词：血管内视镜 高胆固醇血症 高血压 危险因素 冠心病 急性冠状动脉综合征 无症状性斑块破裂 

分 类 号：R541.4[医药卫生—心血管疾病]