白花前胡丙素类似物的半合成  

The Semi-synthesis of Similar Compounds of (^+)-Praeruptorin A

作　　者：孔令义[1] 吴献礼[1] 闵知大[1] 

机构地区：[1]中国药科大学天然药物化学教研室,南京210038

出　　处：《中国药科大学学报》2002年第1期73-75,共3页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目 ( No.2 9872 0 5 8);高等学校优秀青年教师教学科研奖励计划资助课题

摘　　要：AIM To semi-synthesize the similar compounds of (+)-praeruptorin A in order to discover new active compounds. METHODS From natural product Pd-Ib, three similar compounds of (+)-praeruptorin A were obtained purposefully by basic hydrolysis with KOH, reduction with NaBH 4, acylation with acids. RESULTS The structures of synthesized three similar compounds of (+)-Praeruptorin A were 3′( R )-tiglyloxy-4′-keto--3′,4′-dihydroseselin, 3′( S),4′(S ) -diangeloyloxy -3′,4′-dihydroseselin and 3′( S),4′(R )-divaleryloxy-3′,4′-dihydroseselin respectively. CONCLUSION This research work is first semi-synthesis of two known natural product and a new compound from the view of structural modification of (+)-praeruptorin A.AIM To semi-synthesize the similar compounds of (+)-praeruptorin A in order to discover new active compounds. METHODS From natural product Pd-Ib, three similar compounds of (+)-praeruptorin A were obtained purposefully by basic hydrolysis with KOH, reduction with NaBH 4, acylation with acids. RESULTS The structures of synthesized three similar compounds of (+)-Praeruptorin A were 3′( R )-tiglyloxy-4′-keto--3′,4′-dihydroseselin, 3′( S),4′(S ) -diangeloyloxy -3′,4′-dihydroseselin and 3′( S),4′(R )-divaleryloxy-3′,4′-dihydroseselin respectively. CONCLUSION This research work is first semi-synthesis of two known natural product and a new compound from the view of structural modification of (+)-praeruptorin A.

关 键 词：白花前胡丙素 半合成 类似物 提取 分离 结构鉴定 

分 类 号：R284[医药卫生—中药学]