清心饮抗心肌缺血作用的实验研究  

The experimental study of Qingxinyin decoction on myocardial ischemia

作　　者：李佃贵[1] 李振彬[2] 林慧芳[3] 靳文龙[4] 齐静[5] 石建喜[6] 蔡春江[1] 扈国杰[1] 

机构地区：[1]河北省职工医学院,保定071000 [2]中国人民解放军白求恩国际和平医院,石家庄050081 [3]河北省石家庄市第六医院,石家庄050051 [4]河北省卫生厅,石家庄050051 [5]河北省中医院,石家庄050011 [6]中国人民解放军第467医院,石家庄050081

出　　处：《河北中医》2002年第1期71-73,共3页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省自然科学基金资助课题 (编号 :3 993 86)

摘　　要：目的　探讨抗蛇毒中药组方清心饮对实验性心肌缺血的防治效应。方法　采用垂体后叶素 (Pit)致大鼠急性心肌缺血模型 ,观察静脉注射清心饮 ( 0 .5g/kg或 1 .0g/kg)和川芎嗪 ( 1 0mg/kg)对心肌缺血大鼠心电图ST段和T波的影响。结果　清心饮对Pit所致缺血性T波和ST段有明显改善作用 (P <0 .0 5～ 0 .0 0 1 ) ,其防治效果具有剂量依赖性 ,清心饮大剂量组对ST T的改善作用优于川芎嗪 (P <0 .0 5 )。Objective To investigate the effect of Qingxiny in (a kind of traditional medicine compound which is anti-snake venom) in preventing and treating experimental myocardial ischemia of rats. Methods The myocardial ischemia models were made by pituitary injection, the ST segment and T wave of ECG of myocardial ischemia rats were observed after intravenous injection of Qingxinyin (0.5 g/kg or 1.0 g/kg) and Tetramethylpyrazine (10 mg/kg). Results Qingxinyin decoction can improve the changes of ST segment and T wave that caused by pituitary injection (P<0.05～0.001).The effect of preventing and treating pituitary injection myocardial ischemia rats was in a dose dependent manner, high administration group were superior to Tetramethylpyrazine group. Conclusion Qingxinyin decoction may effectively restrain the myocardial ischemia caused by pituitary.

关 键 词：清心饮 抗蛇毒中药 实验研究 抗心肌缺血 心肌缺血 中药 中医药疗法 

分 类 号：R285.5[医药卫生—中药学] R259.422[医药卫生—中医学]