四川省结核病耐药动态及变化趋势  

The Dynamic Chang and Drug Resistance of Tuberculosis in Sichuan Province

作　　者：刘杨椅[1] 段炜[1] 熊国屏[1] 吴建林[1] 曹慧[1] 夏良成[1] 雷伦君[1] 杨筠[1] 邓大志[1] 

机构地区：[1]四川省结核病防治所,成都610036

出　　处：《预防医学情报杂志》2002年第1期9-10,共2页Journal of Preventive Medicine Information

基　　金：四川省卫生厅科研基金 (编号 0 0 0 1 71 )

摘　　要：目的　掌握四川省结核病耐药动态及变化趋势 ,评价结核病控制实施效果。方法　对四川省 1985、1990和 2 0 0 0年 3月结核病流调耐药性调查结果进行分析。结果　① 3次调查结果显示结核病总体、继发耐药率呈下降趋势。②各种药物的耐药发生频率中以INH为最高 ,EMB最低 ;RFP耐药率明显上升 ,INH呈下降趋势。③不同耐药类型的发生频率中耐一药下降 ,含INH +RFP的耐多药率呈上升趋势 ,尤以 2 0 0 0年耐多药率增高明显。结论　四川省结核病总体耐药情况虽呈下降趋势 ,但耐多药率明显增高的情况不容忽视 ,继续贯彻现代结核病控制策略 。Objective To know well the dynamic changes and trends on drug resistance of tuberculosis and to evaluate the effect of tuberculosis control program.Methods Analysing the results of epidemiological survey for drug resistance of tuberculosis in 1985,1990,and 2000 in Sichuan province.Results ①The results showed that there was a decreasing in the rate of total drug resistance and acquired drug resistance of tuberculosis.②The incidence of INH drug resistance was the highest and that of EMB was the lowest;drug resistance rate of RFP is increasing evidently and INH is decreased.③In the incidence of different drug resistance,one drugs resistance rate decreased while multi drug resistance rate increased,including that of INH&RFP,particularly,dramatic in 2000.Conclusion Total drug resistance rate is decreasing,but multi drug resistance rate is increasing.so modern TB Control Program should be implemented continually to stop the epidemic of drug resistance tuberculosis.

关 键 词：耐药性 结核病 动态 变化趋势 控制 四川 流行病学 

分 类 号：R52[医药卫生—内科学]