有氧运动训练对慢性冠状动脉狭窄后侧枝循环生成的初步研究  

A pilot study of exercise on collateral development after gradual coronary artery occlusion

作　　者：黄澎[1] 励建安[1] 袁红洁[1] 王红星[1] 周士枋[1] 

机构地区：[1]南京医科大学,210029

出　　处：《中国康复医学杂志》2002年第1期22-25,共4页Chinese Journal of Rehabilitation Medicine

基　　金：江苏省自然基金资助 (课题号BK9914 2 );人事部留学回国人员科技活动 (A类 ) 1999年度经费资助

摘　　要：目的 :探讨慢性冠状动脉狭窄模型猪有氧运动训练对冠状动脉侧枝循环生成的影响。方法 :健康 3月龄猪18只 (体重 2 2 .5± 2 .0kg) ,采用Ameroid缩窄器使冠状动脉左回旋支形成慢性冠状动脉狭窄模型后 ,进行中等强度有氧运动训练 4周、6周和 8周。采用微粒体技术观察缺血心肌的局部血流改变 ,并通过病理学检查观察形态学改变。结果 :术后存活超过 4周的猪全部稳定形成冠状动脉左回旋支完全闭塞 ,但无心肌梗死。运动组冠状动脉左回旋支血管支配区心肌局部血流量和毛细血管密度较基础值显著增加 (P <0 .0 1) ,且与训练时间呈正相关 (r=0 .73 0 ,P <0 .0 1) ,同时显著高于对照组 (P <0 .0 1)。结论Objective:To study the effect of exercise on collateral development on gradual coronary artery occlusion model. Method:Subjects were 18 pigs (3 month old, 22.5±2.0 kg) with chronic proximal left circumflex coronary artery (LCX) produced by Ameroid constrictor. Four weeks after operation on LCX when the gradual coronary artery occlusion formatted, the subjects were divided into the sedentary group and exercise training group, which performed aerobic treadmill training at moderate intensity for 4, 6 and 8 weeks. Microspheres were employed to measure local coronary blood flow (LCBF). Morphology of local myocardium was examined by histology and microscopy. Result: Complete obstruction in LCX was found in all subjects. LCBF and density of myocardial capillary increased significantly after exercise training ( P <0.01) and the increase of LCBF were more significant in the exercise group than the sedentary group ( P <0.01). Conclusion: Aerobic exercise training facilitates collateral growth in the gradual coronary artery occlusion model.

关 键 词：冠状动脉狭窄 侧枝循环 有氧运动训练 康复治疗 

分 类 号：R49[医药卫生—康复医学]