深低温低流量灌注降温期pH稳态对乳猪脑保护的研究  

Cerebral protection study of pH stat blood gas management on piglets during the cooling perfusion of deep hypothermia low flow

作　　者：王顺民[1] 苏肇伉[1] 徐志伟[1] 朱德明[1] 陈惠文[1] 

机构地区：[1]上海第二医科大学新华医院上海儿童医学中心胸心外科,200127

出　　处：《中华胸心血管外科杂志》2002年第1期25-27,共3页Chinese Journal of Thoracic and Cardiovascular Surgery

基　　金：卫生部资助项目(编号 96-2 -2 88)

摘　　要：目的　在深低温低流量灌注模式下 ,观察快速降温期应用不同血气管理对乳猪脑功能的影响。方法　 12只乳猪随机均分成 2组。alpha组 :降温期应用alpha稳态 ;pH组 :降温期应用pH稳态。脑功能的监测包括 :脑血流量、脑部温度、生化指标 ,并计算脑氧代谢参数和复温末脑水含量。结果　pH组降温末脑血流量和脑皮质ATP含量均高于alpha组 (P <0 0 5 ) ,而脑氧代谢率、乳酸含量和降温期脑部温差均低于alpha组 (P <0 0 5 ) ,两组脑水含量的差异无显著意义。结论　深低温低流量灌注快速降温期应用pH稳态管理血气 。Objective: To estimate the effect of different blood gas management on piglets' cerebral function during rapid cooling in deep hypothermic low flow perfusion. Methods: 12 piglets randomly divided into two groups, each of which contains 6 piglets. Alpha group: alpha stat blood gas management during cooling. pH group: pH stat blood gas management during cooling. Cerebral function measurement included cerebral blood flow, brain temperature, biochemistry factors, brain water content and the parameters of the cerebral oxygen metabolism. Results: Cerebral oxygen metabolism and jugular venous lactic acid in pH group were significantly lower in comparison with alpha group at the end of cooling, while cerebral blood flow and brain cortical ATP in pH group were significantly higher than that in alpha group. The degree of brain temperature gradient in pH group was lower than that in alpha group. No statistical difference of brain water content was found between two groups at the end of rewarming. Conclusion: Better cerebral protection was provided by pH stat blood gas management during rapid cooling in deep hypothermic low flow perfusion.

关 键 词：体外循环 脑保扩 深低温低流量灌注 

分 类 号：R654.1[医药卫生—外科学]