吗啡依赖性大鼠模型的建立  

Rat model for morphine dependenc

作　　者：杨晓红[1] 杨健[1] 吴功柱[2] 

机构地区：[1]川北医学院微生物教研室,四川南充637000 [2]川北医学院附属医院药剂科,四川南充637000

出　　处：《川北医学院学报》2001年第4期1-2,共2页Journal of North Sichuan Medical College

基　　金：省教育厅重点科研项目基金资助 (2 0 0 0 2 5 )

摘　　要：目的 :建立吗啡依赖性大鼠实验动物模型。方法 :以剂量递增法形成吗啡依赖模型 ,用纳洛酮催促戒断 ,戒断症状按柳田知司评分法给予评分。结果 :吗啡组戒断症状分值为 19.6 3± 3.4 6 :生理盐水对照组的戒断分值为 6 .2± 1.6 ,两组相比有显著性差异 (p <0 .0 1)。结论Objective:To establish the model of morphine dependent rats.Method:Rats were given in gradually increasing doses of morphine to produce physical dependencs.Withdrawal syndrome was precipitated by naloxome.Result:The withdrawal score of morphine group and Nsgraup was 19.63±3.46 and 6.2±1.6.There was significant differnece between the groups(P<0.01).Conclusion:The model of morphine dependent rats has been established in treatment of morphin sithdrawal syndrmes.

关 键 词：吗啡 戒断症状 动物模型 动物实验 吗啡依赖性 

分 类 号：R971.7[医药卫生—药品]