海洋低温溶菌酶抗肿瘤活性的初步研究  

Preliminary studies on anti-tumoractivity of marine low-temperature lysozyme

作　　者：张云波[1] 孙谧 蔡勤[2] 王跃军 洪义国 郝建华 

机构地区：[1]中国水产科学研究院黄海水产研究所海洋酶与酶工程开放实验室,青岛266071 [2]中国科学院上海生物工程研究中心,200233 [3]青岛海洋大学海洋生命学院,266003

出　　处：《海洋水产研究》2001年第3期24-31,共8页Marine Fisheries Research

基　　金：国家"海洋 86 3"项目 ( 86 3-819-0 6 -0 1)资助

摘　　要：通过观察海洋低温溶菌酶对体外培养细胞株增殖的影响、对角膜诱生血管的影响、对小鼠肉瘤 S180 (实体型 )及对小鼠肝癌 HAC(实体型 )的抑制作用 ,探讨海洋低温溶菌酶抑制肿瘤生长活性。结果表明 ,该酶与蛋清溶菌酶在抑瘤作用机制上有很大区别 ,海洋低温溶菌酶具有血管生成抑制因子的活性 。The anti tumor effect of marine low temperature lysozyme is studied by means of experiments on its effects on proliferation of cell strains culturing in vitro, and conea inducing vessel, its inhibition to mouse sarcoid S 180 and mouse liver cancer HAC etc.. The resurt shows that the lysozyme differs greatly from white egg lysozyme in their mechanism of inhibition to tumor. The marine low temperature lysozyme has the activity of angiogenesis inhibiting factor, which can inhibit the growth of tumor strikely.

关 键 词：海洋杆菌 低温溶菌酶 血管生成抑制因子 抗肿瘤活性 

分 类 号：R977.3[医药卫生—药品] R979.1[医药卫生—药学]