5个不同企业的盐酸二甲双胍片体外溶出度考察  

Study on the dissolution of metformin hydrochloride tablets of five formulations in vitro

作　　者：谢晓慧[1] 甄健存[1] 赵怀全[1] 

机构地区：[1]北京积水潭医院药剂科,北京100035

出　　处：《中国药学杂志》2001年第7期481-482,共2页Chinese Pharmaceutical Journal

摘　　要：目的　对国内外 5个企业的盐酸二甲双胍片进行体外溶出度考察 ,为临床合理用药提供依据。方法　中国药典 2 0 0 0年版规定的方法。结果　 5个企业在 5个时间点的累积溶出百分率均有显著性差异 (P <0 .0 1)。OBJECTIVE: To investigate the dissolution of metformin HCl of five formulations and to obtain the basis for its rational use. METHOD: According to the first method in Chinese Pharmacopoeia (2000) appendix XC, the rotational speed was 100 r &middot min-1 under the temperature (37.0 ± 0.5)°C. The content was measured by UV spectrophotometry at 233 nm. RESULTS: The dissolution of these samples at five time-point showed significant difference (P < 0.01). CONCLUSION: The results may be used as the basis for rational use of the drug.

关 键 词：盐酸二甲双胍片 体外溶出度 降糖药 

分 类 号：R977.15[医药卫生—药品]