临床常见致病菌对国产美罗培南等6种抗生素敏感性研究  

Studies on susceptibility of clinical isolates to domestic meropenem and other five antimicrobial agents

作　　者：王睿[1] 刘庆锋[1] 薛俊峰[1] 方翼[1] 刘皈阳[1] 赵继红[1] 梅开城[1] 

机构地区：[1]中国人民解放军总医院,北京100853

出　　处：《中国药学杂志》2001年第7期487-489,共3页Chinese Pharmaceutical Journal

摘　　要：目的　比较研究 2 0 0株临床常见致病菌对国产美罗培南与其他 5种抗菌药物的敏感性。方法　采用琼脂平板稀释法测定最低抑菌浓度。结果　国产美罗培南对临床常见致病菌作用与进口美罗培南一致 ;对表皮葡萄球菌和假单胞菌属的敏感率比伊米培南 /西司他丁较高 ;对大多数受试菌的敏感率显著高于头孢他啶 ;对金黄色葡萄球菌和肠球菌属的敏感率显著高于头孢哌酮 /舒巴坦和哌拉西林 /他唑巴坦。结论　国产美罗培南与进口美罗培南的抗菌谱和体外抗菌活性基本一致 ,比伊米培南 /西司他丁及 β内酰胺酶抑制剂复合制剂作用略强或相似 。OBJECTIVE: To study the antibacterial activity of domestic meropenem and other five antimicrobial agents against 200 clinical isolates in vitro. METHODS: The MICs were determined by agar dilution method. RESULTS: The domestic meropenem (MEPM-1) had similar antimicrobial activity with meropenem imported (MEPM-2) and showed higher activity than imipenem/cilastatin against S. epidermidis and Pseudomonas spp. MEPM-1 was markedly active than ceftazidime against most isolates tested; moreover, S. aureus and enterococci were more sensitive to domestic meropenem than cefoperazone/sulbactam and ticarcillin/tazobactam. CONCLUSION: MEPM-1 demonstrated similar antimicrobial activity and spectrum with MEPM-2, slightly active than imipenem/Cilastatin and other β-lactams combined with β-lactamase inhibitors and showed significantly antimicrobial activity than ceftazidime.

关 键 词：美罗培南 细菌敏感性 药敏试验 最低抑菌浓度 合理用药 

分 类 号：R978.1[医药卫生—药品] R969.3[医药卫生—药学]