粘附分子P-选择素在儿童哮喘发病中的作用  

Role of P-selectin in the pathogenesis of asthmatic children

作　　者：钱耀琴[1] 顾洪亮[1] 张少明[1] 王平[1] 胡建芬[1] 

机构地区：[1]上海第二医科大学附属第九人民医院,200011

出　　处：《上海医学》2001年第7期428-429,共2页Shanghai Medical Journal

摘　　要：目的　探讨粘附分子P 选择素在儿童哮喘发病中的作用及其临床意义。方法　应用12 5I SZ 5 1标记的特异性单克隆抗体放免法 ,测定了 72例急性发作期和缓解期哮喘患儿血浆P 选择素水平和肺功能 1秒钟用力呼气容积 (FEV1)及最大呼气流速 (PEF)。结果　显示哮喘患儿急性发作期P 选择素平均水平 (18.6 9±5 .15 )ng/ml ,比正常对照组 (10 .2 8± 1.36 )ng/ml明显升高 (P <0 .0 0 1)。其中重度发作组为 (2 4.36± 5 .5 9)ng/ml较轻、中度发作组 (14.2 9± 0 .91)、(17.43± 1.75 )ng/ml明显升高 ,3组差别非常显著 (P <0 .0 0 1)。同时显示 ,随着P 选择素水平升高 ,肺功能FEV1、PEF值下降亦愈明显 ;缓解期各组哮喘患儿血浆P 选择素水平明显下降 ,肺功能改善。结论　提示粘附分子P 选择素在哮喘的急性发病中起着重要作用 ,其表达可能成为气道急性炎变的标志。测定P 选择素水平为哮喘的诊断及判断病情提供较好的实验室参数。Objective To evaluate the role of p selectin in the pathogenesis of asthmatic children and its clinical significance. Methods The plasma p selectin was separately measured by radioimmunoassay with 125I SZ 51 marked of specific McAb in 72 acute and relieved asthmatic children. The lung functions(FEV1,PEF) were also evaluated. Results The plasma p selectin average level was(18.69±5.15)ng/ml in acute attack group, (10.28±1.36)n/ml in controls lifting significantly(P<0.001). The expression of p selectin seemed higher in serious group(24.36±5.59)ng/ml than that in slight(14.29±0.91) and medium group(17.43±1.75)ng/ml lifting significantly. The difference of 3 groups had a statistically significant (P<0.001). At the same time, the lung functions were dropping with the aggravation of the disease, but plasma p selectin level and lung function were obviously decrease and improved during relieved period. Conclusion The result indicates that p selectin plays an important role in the asthmatic attack. , it is a marker of airway inflammation. The level of p selectin can be used as diagnosis and judgment of asthma.

关 键 词：哮喘 P-选择素 儿童 

分 类 号：R725.6[医药卫生—儿科]