降脂治疗对冠心病并发高脂血症患者血管内皮功能的影响  

THE EFFECT OF LIPID-LOWERING THERAPY TO THE ENDOTHELIAL FUCTION OF PATIENTS WITH CORONARY HEART DISEASE AND HYPERCHOLESTEROLEMIA

作　　者：石仲仁[1] 俞虹[1] 崔燕玲[1] 

机构地区：[1]河北省保定市第二医院,071051

出　　处：《中国煤炭工业医学杂志》2001年第12期1005-1007,共3页Chinese Journal of Coal Industry Medicine

摘　　要：目的　探讨降脂治疗对冠心病并发高脂血症患者的血管内皮功能的保护作用。方法　 48例冠心病并发高脂血症患者在降脂治疗前及治疗 4周后、8周后分别测定了血管内皮功能指标—血浆脱落内皮细胞计数及血管内皮依赖性舒张功能 ,并进行对比分析。结果　降脂治疗前 ,观察组的内皮功能较对照组明显低下 ,经 4周、8周降脂治疗后 ,观察组的内皮功能较治疗前显著改善。结论　降脂治疗可有效改善冠心病并发高脂血症患者的血管内皮功能 ,这可能是其降低冠心病的发生率和病死率的机制所在。Objective To explore the effect of lipid-lowering therapy on the protection of endothelial function of patients with coronary heart disease and hypercholesterolemia. Methods 48 patients with coronary heart disease and hypercholesterolemia were chosen to detect their endothelial function -the serum come-off endothelial cell counts and the vascular endothelium-dependent relaxation before and after lipid-lowering therapy. Contrastive analysis was performed about the indexes. Results The patients' endothelial function before lipid-lowering therapy was significantly lower than that of the control group and was greatly improved after 4 weeks and 8 weeks of treatment. Conclusion Lipid-lowering therapy can reduce the endothelial function of the patients suffering from coronary heart disease complicated with hypercholesterolemia, which may be the major factor to decrease the incidence and mortality of coronary heart disease.

关 键 词：降脂治疗 血管内皮功能 高脂血症 冠心病 并发症 

分 类 号：R541.4[医药卫生—心血管疾病] R589.2[医药卫生—内科学]