CD_(43)CD_(20)及总IgE在鼻息肉组织中表达的研究  

Roles of CD_(43), CD_(20) and local IgE in the pathogenesis of nasal polyps

作　　者：王向东[1] 郭剑锋[2] 张呼和[2] 陶格陶呼 韩德民[1] 诸小侬[1] 范尔钟[1] 李颖[1] 

机构地区：[1]北京市耳鼻咽喉科研究所,100005 [2]内蒙古医学院第一附属医院耳鼻咽喉科

出　　处：《中华耳鼻咽喉科杂志》2001年第5期333-334,T005,共3页Chinese Journal of Otorhinolaryngology

摘　　要：目的　探讨CD4 3 、CD2 0 及总IgE在鼻息肉组织中的表达 ,分析其在鼻息肉发病中的作用。方法　采用免疫组化SP法及HE染色对 2 5例鼻息肉和 2 0例中鼻甲粘膜进行研究。结果　鼻息肉组织中CD+ 43 细胞和CD+ 2 0 细胞、浆细胞数显著多于中鼻甲粘膜组织 (P <0 0 1) ,总IgE阳性表达率为44 %,显著高于中鼻甲粘膜组织的 10 %(P <0 0 5 )。结论　鼻息肉中存在活跃的细胞免疫和体液免疫 ,鼻粘膜局部变态反应可能参与鼻息肉的发病。Objective To estimate the roles of CD 43 , CD 20 and total IgE in the pathogenesis of nasal polyps. Method Twenty-six cases of nasal polyps and 20 cases of mucosa of middle turbinates were used in present study. Results The number of CD + 43 cells,CD + 20 cells and plasma cells in nasal polyps were significantly more than that in middle turbinates (P<0.01). The positive rate of local IgE + cells in nasal polyps was significantly higher than in middle turbinate (P<0.01). Conclusion There were active cellular immunity and humoral immunity in nasal polyps. Local allergy may play a role in the pathogenesis of nasal polyps.

关 键 词：鼻息肉 CD20抗原 总IGE CD43抗原 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]