风寒湿刺激对家兔颈部肌肉及血液组织中氧自由基和前列腺素代谢的影响  

Effects of Stimulation of Wind, Cold and Dampness on Metabolism of Oxygen Free Radical and Prostaglandin in Cervical Muscle and Blood in Rabbits

作　　者：姜杰[1] 施杞[2] 

机构地区：[1]暨南大学医学院中医学系,广东省广州市石牌510632 [2]上海中医药大学骨伤科研究所

出　　处：《中医杂志》2001年第8期489-490,共2页Journal of Traditional Chinese Medicine

摘　　要：为了探讨颈部风寒湿刺激对机体氧自由基及前列腺素的影响,将24只新西兰大白兔随机分为正常对照组、风寒湿组、低头位组、复合模型组4组,每组6只。通过给予风寒湿、低头位刺激,观察受累局部和血液组织中超氧化物歧化酶(SOD)、脂质过氧化物(LPO)、前列腺素E_2(PGE_2)、6-酮-前列腺素F_(1α) (6-keto-PGF_(1α))的变化。结果表明,风寒湿与低头位等颈椎病常见的致病因素可使颈部出现无菌性炎症并使受累局部组织和血液中SOD、LPO、PGE_2、6-keto-PGF_(1α)出现异常。氧自由基及前列腺素代谢异常可能是风寒湿致颈椎病的重要机理之一。In order to probe into effect of stimulation of wind, cold and Sdampness to the cervical part on oxygen free radical and prostaglandins, 24 rabbits were randomly assigned to control group and wind - cold - Sdampness group, head - lowering group and combined model group, 6 rabbits in each group, and changes of superoxide dismutase (SOD),lipid hyperoxide (LPO), prostanglandin E2 (PGE2), 6 -keto -PGF1a in affected local region and blood were observed. Results indicated that the commonly - seen pathogenetic factors of cervical spondylopathy such as wind, cold , dampness and lowering head might cause aspetic inflammation of the cervical part and abnormality of SOD, LPO, PGE2 and 6 - keto - PGF1a in affected local tissue and blood, and abnormal metabolism of oxygen free radical and prostagnadins might be one of important mechanisms of cervical spondylopathy induced by wind, cold and dampness.

关 键 词：氧自由基 前列腺素 颈椎病 风寒湿 家兔 颈部肌肉 血液组织 中医痹证 

分 类 号：R255.6[医药卫生—中医内科学]