纤溶酶原激活抑制物活性与冠心病发病关系  

The relation of plasma plasminogen activator inhibitor activity and coronary heart disease

作　　者：王旭东[1] 王瑾[1] 翟艳玲[2] 朱宇清[1] 傅研[1] 赵相印[2] 

机构地区：[1]首都医科大学附属北京同仁医院急诊科,北京100730 [2]首都医科大学附属北京同仁医院血液科

出　　处：《临床心血管病杂志》2001年第11期511-512,共2页Journal of Clinical Cardiology

摘　　要：目的 :探讨纤溶酶原激活抑制物 (PAI)与冠心病 (CHD)发病的关系。方法 :用免疫化学方法观察测定 145例CHD患者和 130例健康对照者的血浆PAI、纤溶酶原激活物 (PA)活性和胆固醇、甘油三酯 (TG)的血清水平。结果 :CHD组的PAI/PA比值 (1.83± 0 .5 2 )明显高于对照组 [(1.17± 0 .48) ,P <0 .0 5 ],PAI与TG具有显著相关性 (r =0 .45 ,P <0 .0 5 )。结论 :PAI与TG相关性在CHD发生、发展过程中具有重要作用。Objective:To assess the relationship between the plasminogen activator inhibitor (PAI) activity and coronary heart disease (CHD).Method:Blood plasma PAI activity, plasminogen activator (PA) activity, serum levels of cholesterol and triglyceride were measured from 145 patients with CHD and 130 controls using immunochemical assay method.Result:The PAI to PA ratio was significantly higher in CHD patients than that in control subjects〔( 1.83 ± 0.52 ) vs ( 1.17 ± 0.48 ),P< 0.05 〕. Plasma PAI activity was correlated positively with levels of triglycerides(r= 0.45 ,P< 0.05 ).Conclusion:Significantly high activity of PAI is associated with hypertriglyceridemia and high age may be of importance in the pathogenesis of CHD.

关 键 词：纤溶酶原激活抑制物 冠心病 疾病发生 

分 类 号：R541.4[医药卫生—心血管疾病]