桑白皮除粗皮和未除粗皮利尿及急性毒性比较研究  

Comparative Study on Diuretic Effect and Acute Toxicity between Cortex Moriradicis with and without Rough Bark

作　　者：张文娟[1] 徐宝林[1] 孙静芸[1] 

机构地区：[1]浙江省中医药研究院,浙江杭州310007

出　　处：《中成药》2001年第12期887-888,共2页Chinese Traditional Patent Medicine

基　　金："九五"国家重点科技攻关计划 ( 96 90 3 0 2 0 3)

摘　　要：目的 :比较桑白皮去粗皮前后利尿作用及毒性的大小。方法 :利用兔导尿法测兔的尿量 ,Bliss法测小鼠LD50 。结果 :iq 8.4g·kg-1桑白皮未除粗皮、除粗皮水煎剂 ,均能显著增加兔子的尿量。 (P <0 .0 5 ) ,两者间无显著差异 (P >0 .0 5 ) ;经Bliss法计算 ,两者有显著性差异 (P <0 .0 5 )。结论 :桑白皮除粗皮前后对利尿作用无明显影响 。Objective: Compare the effect of diuresis and acute toxicity between Cortex Moriradicis with and without rough bark. Methods: Accumulate and note the amount of urine produced by subjects rabbits by means of rabbit catheterization method, and calculate the LD50 on subjects mice by Bliss method. Results: No matter the decoction of Cortex Moriradicis with rough bark(ig 8.4g/kg) or without rough bark(ig.8.4g/kg) can increase greatly the amount of urine produced by rabbits( P <0.05), but no statistical significance in comparison between the tow groups( P >0.05). The LD50 of the decoction of Cortex Moriradicis with rough bark(ip) in the mice was 10.33±1.67g/kg while the LD50 of without rough bark(ip) was 8.39±1.11g/kg by Bliss method, showing significant difference. Conclusion: The effect on promoting the production of urination between Cortex Moriradicis with and without rough bark was no significant difference. The acute toxicity of Cortex Moriradicis without rough bark was more potent than that's of Cotex Moriradicis with rough bark.

关 键 词：桑白皮 利尿 粗皮 急性毒性 

分 类 号：R285.1[医药卫生—中药学] R285.5[医药卫生—中医学]