口服苦参碱的降酶退黄药效学研究  被引量:7

Pharmacodynamic Study on Reducing Enzyme and Receding Jaundice of Matrine for Oral Use

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作  者:周慧[1] 辛顺妹[1] 马竹卿[1] 

机构地区:[1]上海市长宁区中心医院,上海200336

出  处:《中成药》2001年第12期891-894,共4页Chinese Traditional Patent Medicine

摘  要:目的 :通过苦参碱的降酶退黄的药效学研究 ,为开发苦参碱胶囊做准备 ,从而将在临床治疗中克服苦参碱只能单一地通过静脉滴注给药的不足 ,达到减轻病人痛苦和方便病人用药的目的。方法 :采用α 萘异硫氰酸酯 (以下简称ANIT)所致的小鼠胆汁淤积型黄疸模型 ,在健康小鼠中造成高胆红素血症。结果 :经药效实验证明 :高胆红素血症小鼠经灌胃口服苦参碱 75mg/kg和 10 0mg/kg后 ,血清总胆红素 (TBIL)、结合胆红素 (DBIL)和对照组比较均有显著下降 ;血清谷丙转氨酶 (SGPT)和谷草转氨酶 (SGOT)也均有显著降低。结论Objective: This article had been ready for creating Matrine capsule by reducing enzyme and receding jaundice of Matrine. Matrine would be not only by intravenously guttae but also by oral use in clinical treatment, so the oral drug could reduce the pain and use more easy for patients. Methods: The experiment used cholestatic jaundice model for α naphthy isothiocyanate of mice to make high cholerythrin symptom in healthy mice. Results: Pharmacodynamic experiment proved: TBIL and DBIL of high cholerythrin symptom of mice had been reduced, comparing with control groups by Matrine for oral use(75mg/kg and 100mg/kg), and so do SGPT and SGOT. Conclusion: Matrine for oral use had obvious effect on reducing enzyme and receding jaundice.

关 键 词:苦参碱 降酶退黄 ANIT 胆汁淤积型黄疸 

分 类 号:R285.5[医药卫生—中药学] R259.751[医药卫生—中医学]

 

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