吡喹酮对日本血吸虫卵环卵沉淀试验的影响  

Effect of Praziquantel on Circumoval Precipitin Test (COPT) of Schistosoma Japonicum Eggs

作　　者：闵卫平[1] 黄文长[1] 夏宝芬[1] 

机构地区：[1]江西医学院寄生虫学教研室

出　　处：《江西医学院学报》1990年第4期13-16,共4页Acta Academiae Medicinae Jiangxi

摘　　要：体外用吡喹酮药液处理后的日本血吸虫鲜卵进行环卵沉淀试验(COPT)。0.01μg/ml以下浓度药液不能抑制COPT;0.1ug/ml处理60min,1μg/ml处理30min的虫卵,其COPT环沉率及反应强度显著降低。药液浓度与环沉率及反应强度呈负相关。Circumoval Preclpitin test (COPT)was carried out by using purified Schistosoma Japonicum eggs which were incubated with 0.001--10ug/ml concentrations of praziquantel in vitro for 30--120min previously. The results showed that no inhibition of COPT was noted for eggs which were treated with praziquantel in concentrations below 0.1ug/ml. Both the positive rate and intensity of COPT were sig- nificantly reduced in eggs which were incubated with praziquantel in concentration of 0.1ug/ml for 60 --120min or 1--10 ug/ml for 30--120 min. The relationship between drug concentration and COPT positive rate or reaction intensity showed negative correlationships. It is a new evidence that praziquan- tel has inhibitory effect on eggs of Schistosoma Japonicum by means of immunological method. The significance of COPT inhibition has been discussed.

关 键 词：吡喹酮 药理学 日本血吸虫 环卵沉淀试验 

分 类 号：R978.63[医药卫生—药品] R383.24[医药卫生—药学]