胎兔伤口无瘢痕愈合的形态学和胶原构成研究  

Morphological study and collagen constitute analysis of wound healing in fetal, maternal and adult rabbits

作　　者：冯国平[1] 孙广慈[1] 管正玉[1] 张海明[1] 冯越蹇[1] 何祯平[1] 

机构地区：[1]中国医学科学院中国协和医科大学整形外科医院,北京100041

出　　处：《中华整形外科杂志》2001年第4期239-241,T004-4,共4页Chinese Journal of Plastic Surgery

摘　　要：目的　探讨胎兔伤口无瘢痕愈合的可能机理及条件。方法　用 2 2～ 2 3d的孕兔建立胎兔伤口无瘢痕愈合的动物模型 ,并与孕兔、成年兔伤口愈合进行比较 ,对各组兔皮肤切口组织进行光镜和透射电镜检查 ,胶原含量测定 (羟脯氨酸法 )及分型。结果　①胎兔切口无急性炎症反应 ,成纤维细胞 (FB)出现早 ,伤口无瘢痕一期愈合。②胎兔伤口中胶原含量及构成变化不显著 ;孕兔、成年兔胶原在术后 7d时升高 (P <0 .0 5 )。结论　无急性炎症反应。Objective To investigate the mechanism underlying fetal scarless wound healing. Methods Using maternal rabbits at day 22～23 of pregnancy (term=31～32days), a fetal scarless wound healing model was established. The wound tissue was examined with light and transmission electron microscopy. Total collagen content and the ratio of type III/type I were analyzed using quantification of hydroxyproline content. Results The fetal linear wounds differ markedly from adult wounds in terms of rapid healing, no acute inflammation, no scarring, an early deposition of FB and an early and no excessive collagen deposition. Conclusion Our results showed that no acute inflammation, fetal FB and constitution of collagen might play an important role in fetal scarless wound healing.

关 键 词：胎兔 无瘢痕愈合 成纤维细胞 胶原 形态学 

分 类 号：R622[医药卫生—整形外科]