片剂中红霉素的二次微分简易示波伏安法测定  

Determination of Erythromycin in Tablets by Second-order Differential Simple Oscillographic Voltammetry

作　　者：于浩[1] 张宏芳[1] 郑建斌[1] 

机构地区：[1]西北大学电分析化学研究所,陕西西安710069

出　　处：《分析测试学报》2002年第2期36-38,共3页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目 (29775018);国家教育部高等学校骨干教师资助计划项目 (GG-150-71006-2877);陕西省教育厅自然科学专项基金资助项目 (01JK076)

摘　　要：根据在 pH=10.0的NaOH -H3BO3-KCl支持电解质溶液中 ,红霉素在二次微分简易示波伏安图阴极支 -1.55V(vsSCE)处产生一灵敏峰的示波特性 ,建立了测定药品中红霉素含量的二次微分简易示波伏安法 ;校正曲线的线性范围为2.5×10-6～4.8×10-5 mol/L,相关系数为0.9994 ,检出限为1.2×10-6 mol/L;对8.000×10 -6mol/L红霉素进行7次测定的RSD为1.9 % ,样品的平均回收率为99 % ;该法的特点为仪器简单、简便快速、无需通氮除氧。In 0.1 mol/L NaOH-0.1 mol/L H3BO3-0.1 mol/L KCl buffer solution at pH 10.0 erythromycin causes an incision at-1.55 V(vs SCE) on the cathodic branch of dV/dt-V curve. Based on this oscillographic characteristic a method for the determination of erythromycin content in tablets has been established by second _ order differential simple oscillographic voltammetry. There was a good linearity between erythromycin concentration(mol·L-1) and peak height(V) on second _ order differential simple oscillogram with regression coefficient(r) of 0.999 4. The detection limit, RSD for the determination of 8.000×10-6 mol/L erythromycin(n=5) and recovery of the method were 1.2×10-6 mol/L, 1.9% and 99%, respectively. Compared with polarography and other methods, this method is a convenient method due to its cheap equipment, rapid measurement and no need for oxygen _ eliminated.

关 键 词：示波分析 二次微分简易示波伏安法 红霉素 抗生素 药物含量测定 

分 类 号：R978.15[医药卫生—药品] R927.2[医药卫生—药学]