中药单体原儿茶醛对瘀血证患者单核细胞趋化游走能力的影响  

The Influence of Monomer Protocatechualdehyde on Chemotaxis Wandering Ability of Monocyte of Patient with Blood Stasis Symptom

作　　者：徐宗佩[1] 张伯礼[1] 李尚珠[2] 陈克奇[2] 周宇[2] 张吉正 

机构地区：[1]天津中医学院中医工程研究所,300193 [2]中国医学科学院血液病研究所,300020 [3]朝鲜留学生

出　　处：《天津中医》2002年第1期49-50,共2页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金课题 (39870948)

摘　　要：目的 :探讨瘀血证的本质 ,研究活血化瘀药物的作用机制。方法 :采用两种体外白细胞趋化游走实验(48孔微小趋化室和Transwell共同培养体系),观察瘀血证患者和健康人外周血单核细胞趋化游走能力及原儿茶醛(37℃40ug/mL15分钟)对其影响。结果 :瘀血证患者外周血单核细胞趋化游走能力较健康人非常显著增强 ,P<0.01。原儿茶醛能显著降低瘀血证(P<0.01)及健康人 (P<0.05)外周血单核细胞趋化游走能力。结论 :瘀血证患者单核细胞趋化游走能力增强 ,原儿茶醛能降低瘀血证患者的单核细胞趋化游走能力。Objective: To study the essence of blood stasis symptom and the mechanism of herbs used to activate blood flow and remove blood stasis.Methods: Two kinds of experiments were taken on chemctaxis wandering ability of white blood cells in vitro (48 holes minor chemotaxis room (AC-48) and Transwell Corning Costar).We observed the chemotaxis wandering ability of peripheral monocyte of patients with blood stasis symptom and healthy people, and the influence of protocatechualdehyele on it(37 ℃,40 μg/ml,15 minutes).Results:The chemotaxis wandering ability of peripheral monocyte of patients with blood stasis symptom was greatly improved,compared with that of healthy people.P<0.01.Protocatechual dehyde can reduce the chemotaxis wandering ability of monocyte of patients with booel stasis symptom(P<0.01)and healthy people(P<0.05).Conclusion: The chemotaxis wandering ability of patient with blood stasis symptom is improved, and can be reduced by protocatechualdehyde.

关 键 词：瘀血证 单核细胞 趋化游走 原儿茶醛 病理生理 中药 治疗 

分 类 号：R285.5[医药卫生—中药学] R255.7[医药卫生—中医学]