丹参心俞穴注对急性心肌梗死大鼠血浆TXB_2、6-Keto-PGF1α的影响  

Effects of injection of Danshen at Hsinshu point on the contents of TXB_2 and 6-keto-PGFl α in plasma of rats with acute myocardial infarction and the AMI size

作　　者：张秋玲[1] 张萍[2] 杨国雄[3] 杨勤[3] 

机构地区：[1]贵州省人民医院针灸科,贵阳550002 [2]贵阳市第四人民医院骨科,550002 [3]贵阳医学院病理生理教研室,550004

出　　处：《贵州医药》2002年第2期130-131,共2页Guizhou Medical Journal

摘　　要：目的研究穴位注射对急性心肌梗死大鼠的心梗面积及血浆中TXB2 、6 Keto PGF1α含量影响 ,从而为临床治疗提供客观的科学依据。方法将 6 0只大鼠分为正常对照组 (15只 )、阳性对照组 (15只 )、生理盐水心俞组 (15只 )、丹参心俞组 (15只 ) ,分别测量其心梗面积 ,采用免疫组织化学方法检测血浆中的TXB2 、6 Keto PGF1α含量 ,对其结果进行统计学分析。结果丹参心俞组与阳性对照组、生理盐水心俞组比较 ,心梗面积及血浆中的TXB2 、6 Keto PGF1α含量的差异均有显著意义 (P <0 0 5 )。结论急性心肌梗死大鼠血浆中TXB2 、6 Keto PGF1α含量的变化 ,可能是急性心肌梗死发生的重要体液因素 ,而丹参心俞穴位注射可减少心梗面积并对其含量进行良性调节。Objective To study the effects of point injection on the contents of TxB 2 and 6-Keto-PGFl α in plasma of rats with AMI and the AMI size. Methods 60 rats were classified into average normal control group, positive control group, normal saline group, Danshen point injection group. The infarct sizes of all rats were measured, the contents of TXB 2 and 6-Keto-PGFl α in all rats were detected by immunogistochemical method. Results Danshen group, compared with positive contrast group, and normal saline group had significantly difference ( P <0.05) in infarct size and the contents of TXB 2 and 6-Keto-PGFl α. Conclusion The variations of TXB 2 and 6-Keto-PGFl α contents and reduce of infarct size might be an important humoral factor for the onset of AMI and Danshen injection at Hsinshu point had favorable effects on the adjustment of their contents, and reduce of infarct size.

关 键 词：丹参液 穴位注射 急性心肌梗死 心梗面积 大鼠 TXB2 6-Keto-PGFlα 血浆 心俞穴 

分 类 号：R542.22[医药卫生—心血管疾病]