肝素体外诱导低密度脂蛋白-脂蛋白α-纤维蛋白原沉淀分离术36例临床分析  

Heparin-induced extacorporeal low-density lipoprotein-lipoprotein α-fibrinogen precipitation in36cases

作　　者：莫建坤 黎永新 雷达 吴德海 

机构地区：[1]广东省一七七医院检验科,广东广州510317

出　　处：《第一军医大学学报》2002年第3期278-279,共2页Journal of First Military Medical University

摘　　要：目的探讨肝素体外诱导低密度脂蛋白-脂蛋白α-纤维蛋白原沉淀分离术(heparininducedextacorporealLDL-LPα-fibrinogenprecipitation,简称血脂分离术)对脂蛋白的分离清除效果。方法用血脂分离仪器在体外肝素诱导低密度脂蛋白胆固醇(LDL-C)、脂蛋白、纤维蛋白原、甘油三脂,形成肝素-LDL-C-纤维蛋白原形成复合物而被沉淀,最后被分离出来。结果术后病人各项血脂指标与血脂分离前测定结果比较显著降低(P<0.001)。结论血脂分离术确实可以达到分离清除部分血脂的目的。Objective To observethe efficacyof heparin-inducedextracorporeallow-densitylipoprotein-lipoproteinα-fibrinogenprecipitation(HELP)inclearingbloodlipids.Methods Thirty-sixpatientsweresubjectedto extracorporealplasma lipidseparationproceduresthatutilizedheparinto inducetheformationof thecomplexconsistedof heparin,low-density lipoproteincholesterol(LDL-C),lipoproteinandfibrinogenwhichwas precipitatedandconsequentlyseparatedfromthe plasma.Bloodsampleswereobtainedfromthepatientsbothbeforeandaftertheproceduresto assayserumtotalcholesterol(CH),triglyceride(TG),high-densitylipoproteincholesterol(HDL-C),LDL-C,apoliproteinA(ApoA)andapoliproteinB(ApoB).Result Significantdifferenceswereobservedbetweenthepre-andpostoperativelevelsof lipoprotein(P<0.001).Conclusion Plasmalipoproteincanbe partlyclearedby wayof HELP

关 键 词：低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 肝素 脂蛋白类 纤维蛋白原 沉淀分离术 体外诱导 血脂分离术 

分 类 号：R589.2[医药卫生—内分泌]