氯沙坦对高血压病患者QT离散度影响的临床研究  

The Clinical Research in the Effect of Losartan on QT Interval Dispersion of the Essential Hypertension Patients

作　　者：薛晶[1] 李中言[1] 陈丹[1] 李香莲[1] 

机构地区：[1]第四军医大学吉林军医学院附属医院心内科,吉林132013

出　　处：《医学文选》2002年第1期6-7,共2页Anthology of Medicine

摘　　要：目的　研究氯沙坦对高血压病患者 QT离散度的影响。方法　 96例高血压病患者通过超声心动图划分为左室肥厚组 64例 ,无左室肥厚组 32例 ,与 30例健康对照组进行 QTd、QTlcd的测定。随机选出40例行常规降压治疗 ,另 5 6例在常规治疗基础上加用氯沙坦 ,血压降至理想水平 6个月后复测 QTd、QTlcd。结果　 1 .高血压左室肥厚患者的 QTd明显高于非左室肥厚及健康者 ;2 .氯沙坦治疗 6个月后左室肥厚逆转、QT离散度明显缩小。结论　高血压左室肥厚与 QT离散度增加有关 ;氯沙坦可明显减小高血压左室肥厚程度及 QT离散度 。Objective To study the Effect of Losartan on QT Interval dispersion of the Essential Hypertension Patients Methods Of 96 hypertension cases classified the left ventricular hypertrophy(LVH) group(64 cases) and Non left ventricular hypertrophy(non LVH) group(32 cases) according to echocardiogram 40 cases were chosen at random and received routine anti hypertension treatment,while the other 56 cases were treated with Losartan on the basis of the routine anti hypertension treatment In contrast to 30 healthy control persons,all the persons were examined QTd and QTlcd before and 6 months after treatment Results 1 The QTd in hypertension with left ventricular hypertrophy is remarkably longer than that of non left ventricular hypertrophy and healthy person;2 Left ventricular hypertrophy was reversed and QTd was decreased remarkably after treatment 6 months with Losartan Conclusions Left ventricular hypertrophy in hypertension is related to QTd prologing;Losartan can reverse left ventricular hypertrophy and diminish the QTd in hypertension significantly,and then decrease the incidence of cardiovascular affairs

关 键 词：高血压 左室肥厚 QT离散度 氯沙坦 治疗 

分 类 号：R544.1[医药卫生—心血管疾病]