军队多地域高血压病随机、双盲国产药物干预研究  

RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL OF THE ANTIHYPERTENSIVE EFFICACY OF BISOPROLOL,ENALAPRIL AND NIFEDIPINE RETARD ON PATIENTS IN THE TROOPS IN DIFFERENT GEOGRAPHICAL REGIONS

作　　者：刘国树[1] 李鸣凤[1] 石湘芸[2] 李玉芝[3] 郑开元[3] 郭勇梅 邹仁民 张明华[1] 

机构地区：[1]北京解放军总医院 [2]海军总医院 [3]成都军区西藏总医院 [4]北京军区机关门诊部

出　　处：《解放军医学杂志》2002年第3期277-279,共3页Medical Journal of Chinese People's Liberation Army

基　　金：全军医学科研"九五"计划面上项目资助课题 (编号 96M1 4 4 )

摘　　要：采用随机、双盲对照法 ,将“军队多地域高血压抽样队列调查”检出的轻、中度高血压病患者 2 6 5例 (北京地区 37例 ,西藏地区 86例 ,海军 14 2例)分为比索洛尔组 (5mg/d)、依那普利组 (10mg/d)、缓释硝苯地平组 (2 0mg/d) ,治疗期限 4周。以诊室血压 (CBP)为指标比较三种药物的降压疗效 ,并观察不同地域对上述三种降压药物疗效的影响。结果表明 ,三种药物均能有效降低三个地域高血压病患者的CBP(P <0 0 5 )。北京地区、西藏地区和海军部队患者比索洛尔治疗的总有效率分别为 71 4 %、81 2 %和 83 0 % (P >0 0 5 )。西藏地区和海军患者依那普利治疗的总有效率分别为 96 0 %和 77 6 % (P <0 0 5 )。西藏地区和海军患者缓释硝苯地平治疗的总有效率分别为93 1%和 76 1% (P >0 0 5 )。This was a randomized, double blind clinical trial. 265 patients with mild to moderate hypertension in the troops in different geographical regions (Beijing, Tibet and coastal area) were randomly allocated to receive bisoprolol (5mg/day),enalapril (10mg/day) or nifedipine retard (20mg/day). Total duration of active drug treatment was 4 weeks.Results showed that the total efficacy rate of bisoprolol treatment of patients in Beijing, Tibet and coastal areas was 71 4%, 81 2% and 83 0%, respectively( P >0 05). For enalapril treatment, the total efficacy rate in patients in Tibet and coastal areas was 96 0% and 77 6%( P <0 05), respectively, and for nifedipine retard,the total efficacy rate was 93 1% and 76 1%, respectively( P >0 05).

关 键 词：药物治疗 随机对照试验 高血压 军队 多地域 干预研究 

分 类 号：R544.1[医药卫生—心血管疾病]