维生素K对超量P-乙酰氨基酚所致肝损伤的保护作用  

Protective Effect of Vitamin K on Hepatic Damage Caused by Overdose of Paracetamel in Mice

作　　者：黎煌久[1] 陈焕昭[2] 李伟明[1] 刘幸平 

机构地区：[1]汕头大学医学院生物化学教研室 [2]汕头大学医学院药理学教研室

出　　处：《汕头大学医学院学报》1997年第4期7-9,共3页Journal of Shantou University Medical College

摘　　要：观察维生素K对P－乙酰氨基酚（500mg／kg）灌胃所致小鼠肝损伤的影响。结果表明：维生素K能减轻P－乙酰氨基酚引起的小鼠血清丙氨酸转氨酸（SALT）活性升高和肝糖原含量的下降以及肝损伤的病理性变化。维生素K也能降低P－乙酰氨基酚（1000mg／kg）灌胃所致的小鼠死亡率，但差异没有显著性（P＞0．05）。上述作用维生素K3均比维生素K1强。The effect of vitamin k1 and k3 on liver damage in mice induced by the overdose of Paracetamel was reported. The results showed that vitamin k decreased the elevated Serum Aladdin Transaminase (SALT) and increased the content of hepatic glycogen and ameliorated the pathological damage of the liver due to overdose of paracetamol inmice. Vitamin K3 seemed to decrease the mortality of mice as well. The potency of viamin k1 was much weaker than that of vitamin k3. So, vitamin k can be used as an adjutant in the treatment of hepatic diseases.

关 键 词：维生素K P-乙酰氨基酚 肝毒性 护肝药 

分 类 号：R977.26[医药卫生—药品]