酮康唑所致之药物性肝损害──附2例报告及24例综合分析  

Liver Injury Induced by Ketoconazole-2 Cases Report and 24 Cases Review.

作　　者：计叔钧[1] 梁扩寰[1] 

机构地区：[1]同济医科大学同济医院内科

出　　处：《胃肠病学和肝病学杂志》1995年第3期204-206,239,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：酮康唑所致之药物性肝损害──附２例报告及２４例综合分析计叔钧，梁扩寰（同济医科大学同济医院内科武汉４３００３０）酮康唑（ｋｅｔｏｃｏｎａｚｏｌｅ）系口服抗真菌药，常用于手、足癣或念珠菌感染等，但它对肝脏之损害往往被临床所忽视，故报导甚少。本文报告我院...This article reported 2 cases of liver injury induced by ketoconazole and reviewed 24 cases extensively. We provided general material and clinical data,also analyze the causes of liver injury.The results showed that ketoconazole can inhibit the activity of hepatic enzyme and damage the liver cells. Clinical manifestation of liver injury induced by ketoconazole include tender hepatomegaly,nausea,vomiting,and,in the more severe cases,increasing jaundice and signs of liver failure. Laboratony findings include variable increase in serum transaminase activity and bilirubin.

关 键 词：药物性 肝损伤 酮康唑 抗真菌药 

分 类 号：R595.3[医药卫生—内科学] R978.5[医药卫生—临床医学]