油茶子皂甙在体外的杀精子作用  

Spermicidal Action of Sasanquasaponin in Vitro

作　　者：高望新[1] 李宝华[1] 

机构地区：[1]江西医学院药理学教研室

出　　处：《江西医学院学报》1991年第4期11-14,共4页Acta Academiae Medicinae Jiangxi

摘　　要：在体外测试了油茶子皂甙对小白鼠和人精子的杀精子作用,并且与盖苯醇醚和醋酸苯汞的杀精作用进行了比较。结果发现,茶皂甙对小白鼠的杀精子作用(最低有效浓度=10μg/ml)比盖苯醇醚(最低有效浓度=40μg/ml)和醋酸苯汞(最低有效浓度=20μg/ml)的作用更强。但对人精子的杀精作用(最低有效浓度=100μg//ml)比盖苯醇醚(最低有效浓度=50μg/ml)更弱。还证明,人精浆可减弱茶皂甙的杀小鼠附睾精子作用。The Spermicidal effect of sasanquasaponin in vitro on spermatozoa of mice and human was determined and compared with that of methylphenoxypolyethanol (MPPE) and phenylmercuric acetate (PMA). The results showed that the spermicidal effect of sasanquasaponin (MEC=10 μg/ml)on mouse spermatozoa was more potent than that of MPPE (IMEC=40 μg/ml) and PMA (MEC=20 μg/ml). But on human spermatozoa sasanquasaponin (100 μg/ml)was weaker than that of MPPE (MEC=50 μg/ml)and PMA(MEC=50 μg/ml). The spermicidal effect of sasanquasaponin on spermatozoa of mice can be reduced significantly by human semen.

关 键 词：杀精子剂 药理学 油茶子皂甙 

分 类 号：R285.5[医药卫生—中药学]