病毒性肝炎患者血清Ⅲ型前胶原肽的动态检测  

Dynamic Detection of Serum Type Ⅲ Procollagen Peptide in Patients with Viral Hepatitis

作　　者：张国豹[1] 陈世春[1] 蔡锡麟[2] 熊祖廉 范骏[1] 赵令武 

机构地区：[1]江西医学院传染病学教研室 [2]江西医学院核医学教研室

出　　处：《江西医学院学报》1992年第3期13-17,共5页Acta Academiae Medicinae Jiangxi

摘　　要：本文对162例病毒性肝炎患者血清Ⅲ型前胶原肽(SPⅢP)进行动态检测,并与 B 超及有关生化测定结果对照分析。结果各型肝炎的 SPⅢP 均高于正常入水平,其中,以慢重肝和慢活肝组最显著(P<0.01);亚重肝组 SPⅢP 随病程延长而逐渐升高;急性肝炎则于恢复期趋于下降;肝硬化 SPⅢP 水平状况与白/球蛋白比值明显相关(r=0.6523),并与超声影像的检查结果相一致(r=0.7408)。认为肝炎患者动态检测 SPⅢP 有助于早期预示和监测肝纤维化的发展与活动状态。Dynamic detection of serum type Ⅲ procollagen peptide (SP Ⅲ P)in one hundred and sixty two patients with viral hepatitis was compared with type B ultrasonography and relevant biochemical analy- ses.The results showed that levels of SP Ⅲ P in various types of hapatitis were higher than that of nor- mal human especiall in patients with severe chronic hepatitis and chronic active hepatitis(P<0.01). The SP Ⅲ p in patients with subacute severe hepatitis increased gradually with the course of disease,but decreased in those with acute hepatitis during convalescence.The level of SP Ⅲ P and serum A/G ratio in liver cirrhosis were significantly corraleted (r=0.6523) and coincided with ultrasonography (r= 0.7408).It is suggested that dynamic detcetion of SP Ⅲ p in patients with viral hepatitis is helpful in predicting and monitoring the development of hepatic cirrhosis.

关 键 词：病毒性肝炎 免疫学 肽类 分离 提纯 

分 类 号：R512.603[医药卫生—内科学]