原发性高血压过氧化物及超氧化物歧化酶与血脂血粘度相关性观察  

An Observation on the Relation of SOD in Erythrocytes and Serum LPO Peroxides to Serum Lipid and Blood Viscosity in Patients with Essential Hypertension

作　　者：杨露芳[1] 龙怡道[1] 吴旭秀 罗伟 姚陆远 丁先兰 

机构地区：[1]心血管研究所

出　　处：《江西医学院学报》1993年第1期23-27,共5页Acta Academiae Medicinae Jiangxi

摘　　要：本文观察了74例原发性高血压病人红细胞内超氧化物歧化酶(SOD),血清过氧化脂质(LPO),总胆固醇(TC),甘油三酯(TG),高密度脂蛋白胆固醇(HD-C),高切率及低切率全血比粘度,血浆比粘度,红细胞压积(HT)、血沉(ESR)水平及其相互关系。并与46例正常人作对照。结果发现病人血LPO、TC、TG、高切率及低切率全血比粘度、血浆比粘度均显著增高;SOD与TC,高及低切率全血比粘度,LDL-C、LDL-C/HDL_C呈显著负相关,与HDL-C/TC呈显著正相关;LPO与年龄、收缩压、TC、血浆比粘度、LDL-C、LDL-C/HDL-C呈显著正相关,与SOD及HDL-C/TC呈显著负相关;老年组(60～70岁)SOD值显著低于老年前期组(40～59岁),LPO值显著高于老年前期组。提示原发性高血压中SOD、LPO、血脂及血粘度的改变在其病理过程中有协同作用。The values of superoxides (SOD) in erythrocyte, serum lipid peroxide (LPO) total cholesterol (TC), triglyceride (HDL-C), whole blood relative viscosity (WBRV), plasma relative viscosity (PRV). haematokritwert (HT) and erythrocyte sedimentation rate (ESR) have been measured in 74 patients with essential hypertension and 46 normal subjects. The results showed: (1) The mean values of LPO, TC, TG, WBRV, PRV of patients with essential hypertension were significantly higher than those of normal subjects, but the mean value of SOD was lower (P<0.01). (2) SOD was negatively correlated with TC, low density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C and WBRV (r=-0. 317, P<0.01:r=-0.364, P<0.01:r=-0.55, P<0.01 and r=-0.282, P<0.05 respectively) but positively correlated with HDL-C/TC (r=-0.329, P<0.01). (3) LPO was positively correlated with age, systolic blood pressure, TC and PRV (r=0.229, P<0.05,r=0.35,P<0.01;r=0.544,P<0.01 and r=0.236, P<0.05 respectively) but negatively correlated with SOD (r=-0.467, P<0.01) and HDL/TC (r=-0.317, P<0.01 ). (4) The value of the SOD decreased but that of LPO increased with increase of age. It is suggested that changes in SOD. LPO, Blood lipid and blood viscosity correlated with one another in the pathogenesis of essential hypertension.

关 键 词：过氧化脂质 脂类 超氧化物歧化酶 血液粘度 高血压 

分 类 号：R544.103[医药卫生—心血管疾病]