缬沙坦对老年高血压病患者肾素-血管紧张素系统和血管内皮功能的影响  

Antihypertensive effect of valsartan and lts influence on RAS and vascular endothelial function in the elderly patients with hypertension

作　　者：吴绥生[1] 陈冬梅[1] 王文志[2] 

机构地区：[1]吉林大学第一医院,吉林长春130021 [2]吉林大学第三医院

出　　处：《中国老年学杂志》2002年第1期9-10,共2页Chinese Journal of Gerontology

摘　　要：目的　探讨缬沙坦对老年高血压病患者的降压疗效及对肾素 -血管紧张素系统 (RAS)和血管内皮功能的影响。方法　 36例老年高血压患者 ,给予缬沙坦 80～ 1 60 mg/ d口服 ,共 8w,监测治疗前后血压。用放射免疫法测定治疗前后血浆肾素活性 (PRA)、血管紧张素 (Ang )、醛固酮 (AL D)及内皮素 (ET)、一氧化氮 (NO)水平。结果　 (1 )治疗后血压下降总有效率为 86.6% (P <0 .0 1 ) ;(2 )治疗后血浆 PRA、Ang 水平增高 ,ALD水平降低 ,治疗前后有显著差异 (P <0 .0 1 ) ;(3)治疗后血浆 ET水平降低 ,而 NO水平增高 ,治疗前后有显著性差异 (P <0 .0 1 )。结论　缬沙坦治疗老年高血压降压疗效明显 ,对 RAS阻断更完全 。Objective To discuss the effectiveness of antihypertensive treatment and its effect on RAS and vascular endothelial function of the elderly patients with hypertension.Methods 36 patients were treated with valsartan 80～160mg qd.po for 8 weeks,monitoring the blood pressure before and after treatment, and examining plasma renin activity(PRA),Angiotension II (AngII),Aldosterone (ALD),endothelin (ET) and nitric oxide (NO) by radioimmunoassay. Results (1)Valsartan group's total decompression effective rate is 86.6%(P<0.01).(2)After 8 weeks treatment,levels of AngII and PRA in valsartan group increase, and aldosterone decreases (P<0.01).(3)After the treatment, ET level decreases and NO level increases(P<0.01). Conclusions Valsartan is more efficient in the elderly hypertension.In addition,it blocks RAS more completely and is able to meliorate vascular endothelial function.

关 键 词：高血压 缬沙坦 肾素-血管紧张素系统 血管内皮功能 老年人 放射免疫法 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]