大剂量胸腺素对类风湿关节炎临床症状及免疫指标的影响  

Affect of large dose thymosin on clinical symptoms and immune indices of rheumatoid arthritis

作　　者：陈适[1] 穆荣[1] 贾园[1] 马本良[1] 

机构地区：[1]北京医科大学附属人民医院风湿科,北京100034

出　　处：《中国新药与临床杂志》2002年第3期163-165,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :研究大剂量胸腺素对类风湿关节炎的临床症状及免疫指标的影响。方法 :将 5 2例类风湿关节炎病人随机分胸腺素组和对照组 ,均给予甲氨蝶呤及双氯芬酸治疗。胸腺素组同时给予胸腺素80～ 12 0mg ,iv ,gtt,qd× 8wk。结果 :胸腺素组与对照组比较在休息痛、晨僵时间、关节肿胀数、医生评估、α 酸性糖蛋白、血红蛋白、CD4 /CD8、病人评估等方面有明显改善 ,其中晨僵时间缩短值和CD4 /CD8增加值 ,胸腺素组为 (98± 5 3)min和 0 .5± 0 .3,对照组为 (70± 38)min和 0 .3± 0 .4 (P <0 .0 5 )。结论 :大剂量胸腺素对类风湿关节炎治疗作用肯定 ,无不良反应 。AIM: To investigate the effect of large dose thymosin on clinical symptoms and immune indices of rheumatoid arthritis (RA). METHODS: Fifty two patients with RA were randomly divided into a treatment group (twenty six patients given thymosin 80 120 mg, iv, gtt, qd for 8 wk) and a control group (twenty six patients given no thymosin). Blood samples were taken from fore arm vein before and 8 wk after the treatment. RESULTS: Controlled studies showed that thymosin 80 120 mg administered intravenously daily for up to 8 12 wk had significantly improved resting pain, morning stiffness, numbers of swelling joints and physician global assess in treatment group as compared with control group ( P < 0.05 ); and significantly improved AAG, Hb, CD 4/CD 8 and patient global assess in treatment group as compared with control group ( P <0.01). CONCLUSION: Administering thymosin may be effective for RA and there is no adverse reactions. That can be used as an adjunctive therapy.

关 键 词：胸腺素 类风湿关节炎 免疫抑制剂 临床症状 自身免疫性疾病 大剂量 

分 类 号：R979.5[医药卫生—药品] R593.22[医药卫生—药学]