IVF-ET周期中GnRH-a、FSH、hMG配伍方案的比较研究  

The Comparative Study of Different Protocols Using GnRH-a. FSH. hMG for Ovarian Stimulation in IVF Cycles

作　　者：邓晓惠[1] 张慧琴[1] 于红玲[1] 董 艳[1] 闫 旻[1] 杜丽娟[1] 翟 旭 

机构地区：[1]山东大学齐鲁医院妇产科生殖中心,济南250012 [2]德州市德城区妇幼保健院,妇产科德州253017

出　　处：《生殖与避孕》2002年第1期36-39,共4页Reproduction and Contraception

摘　　要：目的:探讨IVF周期中采用不同促排卵方案时,卵泡液及血清中FSH、LH、E2水平的变化及对胚胎发育、受精、妊娠的影响;单用国产hMG促排卵的效果。方法:120例分成4组。测定卵泡液及取卵日血清中FSH、LH、E2水平,比较四种方案的取卵数、受精率、Ⅰ级、Ⅱ级胚胎形成率和每移植周期妊娠率。结果:四种促排卵方案的卵泡液和血清FSH、E2水平没有差别（P>0.05）,不同垂体降调节者,卵泡液和血清LH水平明显升高（P<0.0001）,四种促排卵方案的取卵数、受精率、优质胚胎形成率、移植周期妊娠率经统计学处理均无显著性差异。结论:卵泡液和血清中LH水平升高可能与应用垂体降调节有关,而与选择纯FSH还是hMG促排卵无关。轻度LH升高并不影响卵泡发育、卵子质量和以后的胚胎发育。IVF周期首选垂体降调节加FSH或FSH/hMG促排卵方案,单用hMG促排卵也可以作为选择。ve: To evaluate the efficacy of different ovulating induction protocols during IVF cycles, taking into account the changing of FSH,LH and E2 in follicle fluid and serum. Methods: 120 women un-dergoing IVF cycles were included in this study. Four different protocols were used to induce ovulation. FSH,LH and E2 levels in follicle fluid and in serum were measured. Compared the amount of oocytes re-trieved, fertilization rate, percentage of grade I and grade II embryos, pregnancy rate per ET cycle. Results: There were no statistic different in follicle fluid and in serum FSH and E2 levels among four groups (P>0. 05). Significantly higher LH levels were found in group without long protocol pituitary de-sensitization (P<0. 0001). No statistic different were found in amount of oocytes retrieved, fertilization rate, percentage of grade I and grade II embryos, pregnancy rate among four groups. Conclusions: The slight elevation of LH in follicle fluid did not affect the development and maturation of ovum. The first choice for ovarian stimulation in IVF cycles is FSH or FSH/ hMG combined therapy with pituitary desensi-tization. Using hMG alone may also get satisfied pregnancy rate.

关 键 词：卵泡刺激素 促性腺激素 体外受精 超促排卵 不孕症 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]