体内自固化载药人工骨的制备及修复实验  

Study on the preparation of drug-loaded composite for bone-repair and its effect on fracture-healing in rabbits

作　　者：张勤[1] 高伟[2] 曾仁杰[1] 孙伟张[1] 谭映军[1] 张丽茹[1] 

机构地区：[1]成都军区总医院药学部,四川成都610083 [2]四川省第五人民医院药剂科,四川成都610010

出　　处：《中国药学杂志》2002年第2期113-115,共3页Chinese Pharmaceutical Journal

摘　　要：目的　加入不同比例的改性剂 ,制备不同的体内自固化骨修复材料 ,并通过对家兔进行修补实验 ,考察改性剂对材料特性的影响。方法　乙基纤维素作为药物的缓释载体和改性剂 ,与市售的体内自塑型骨修材料制备成复合物 ,对家兔腿的人造缺损腔进行修补。结果　加入的改性剂具有药物缓释载体和改善市售骨修复材料的特性。结论　采用可降解乙基纤维素可作为对骨缺损的病灶治疗药物的缓释载体 ,按实验方法以 3%制备复合材料的修补特性与市售修复材料相比 。OBJECTIVE To prepare the composite with different amount of microcapsule and study the repair effect of the composite in rabbits.METHOD Ethyl cellulose was used as the carrier and plasticizer to prepare the composite and repair of the artificial bone defect in rabbit was monitored.RESULTS The plasticizer was used as the sustained release carrier and improved the characteristics of the commercial material.CONCLUSION The microcapsule was used as the drug carrier and plasticizer simultaneously.3% microcapsule composite had the better bone repair characteristics.The drug loaded in the composite had the sustained release profile.

关 键 词：自固化 人工骨 乙基纤维素 修复 骨修复材料 药物缓释载体 

分 类 号：R318.08[医药卫生—生物医学工程] R944.9[医药卫生—基础医学]