输精管绝育术对实验性家兔动脉粥样硬化症的影响  

INFLUENCE OF VASECTOMY TO THE EXPERIMENTAL RABBIT ATHEROSCLEROSIS

作　　者：刘世沧[1] 何才春 唐光华 

机构地区：[1]华西医科大学法医学系病理教研室,四川省计划生育科研所病理研究室

出　　处：《四川解剖学杂志》1995年第1期1-6,共6页Sichuan Journal of Anatomy

摘　　要：本文报告家兔输精管绝育术后的免疫反应对实验性动脉粥样硬化的影响。实验动物２０只，分为４组，每组５只。Ａ、Ｂ组作输精管绝育术，而Ｃ、Ｄ组不作手术；在绝育术２０周对Ｂ组与Ｃ组一起用高脂饮食喂养２５周；Ｄ组为空白对照，整个实验共为１０月左右（４５周）。各组同时结束实验。病理组织学检查，绝育组动物（Ａ、Ｂ）睾丸和附睾局部精子淤滞并破入间质引起反应。在高脂饮食组（Ｂ、Ｃ）中：输精管绝育Ｂ组有３只，未绝育Ｃ组有２只的主动脉和颈总动脉肉眼可见粥样化斑形成；镜检１０只动物皆有不同程度的类脂沉着，两组比较，无明显差异。本动物实验研究不能证明输精管绝育术能促进动脉粥样硬化的发展。Twenty Japanese white rabbits were divided into A, B, C, D four groups. There are five animals in each group. The rabbits of Group A and B were used for vasectomy. Twenty weeks post-vasectomy, the rabbits of group B and C were fed with high-fat diet through twenty-five weeks. Group D was used for control. Rabbits of each group were sacrified in the same time. Pathologic investigations showed that sperm stasis, intestitial lymphocytic infiltrations and sperm-granulomas were found in epididymis of vasectomised groups (A, B).There were three vasectomised (B) and two non-vasectomised (C) rabbits showed macroatherosclerotic lesions in aorta and common carotid artery in rabbits with high fat diet. Microscopically.all of the ten rabbits of B, C group showed lipoid deposition and active phagocytosis,but there were no apparent difference between the two groups. The result of this priliminary study shows that the sperm immunity does't influence the formation of atherosclerosis.

关 键 词：输精管绝育术 睾丸 附睾 动脉粥样硬化 兔 

分 类 号：R699.8[医药卫生—泌尿科学] R541.5[医药卫生—外科学]