大叶钩藤中非生物碱成分对骨肉瘤细胞增殖的影响  

Effect of non-alkaloid components in Uncaria macrophylla Wall. on proliferation of osteosarcoma cells

作　　者：杨君[1] 张有为[2] 宋纯清[3] 胡之璧[3] 

机构地区：[1]复旦大学药学院天然药物化学教研室,上海200032 [2]日本东京医科齿科大学细胞生理研究室 [3]上海中医药大学中药研究所,上海200032

出　　处：《植物资源与环境学报》2001年第4期55-56,共2页Journal of Plant Resources and Environment

基　　金："九五"国家重点科技攻关资助项目 (9690 3 0 2 0 3 )

摘　　要：The anticancer activity of non-alkaloid components in Uncaria macrophylla Wall. was studied. The results indicated that ursolic acid showed the strongest activity of inhibiting the proliferation of tumor cells; 3β-6β-23-trihydroxyurs-12-en-28-oic acid, β-sitosterol and 3β-6β-19α-trihydroxyurs-12-en-28-oic acid possessed the same activity, too.The anticancer activity of non-alkaloid components in Uncaria macrophylla Wall. was studied. The results indicated that ursolic acid showed the strongest activity of inhibiting the proliferation of tumor cells; 3β-6β-23-trihydroxyurs-12-en-28-oic acid, β-sitosterol and 3β-6β-19α-trihydroxyurs-12-en-28-oic acid possessed the same activity, too.

关 键 词：大叶钩藤 非生物碱成分 乌索酸 抗肿瘤活性 骨肉瘤细胞 增殖 

分 类 号：R285[医药卫生—中药学]