糖尿病患者血小板四项参数及红细胞变形能力的研究  

Study of 4 Parameters of Platelet and Red Blood Cell Deformability in Diabetic Patients

作　　者：李玉红[1] 陈宗铠[1] 

机构地区：[1]天津医科大学第二医院血液内分泌科,300211

出　　处：《天津医药》2002年第1期8-10,共3页Tianjin Medical Journal

摘　　要：目的:探讨血小板4项参数及红细胞变形指数(DI),在糖尿病及其微血管并发症中的变化及意义。方法:分别应用全自动血细胞分析仪和激光衍射红细胞变形仪,测定100例糖尿病患者和80例健康对照者的血小板平均体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)、血小板计数(PLT)和DI,观察它们在正常人和糖尿病患者不同发展阶段的变化。结果:糖尿病患者MPV、PDW均高于对照组,DI低于对照组,有微血管病变者变化更显著。MPV与空腹血糖(FPG)呈正相关(r=0.673,P<0.01),DI与FPG呈负相关(r=-0.412,P<0.05)。结论:监测MPV、PCT、PDW及DI可早期发现糖尿病微血管病变以便及早防治。Objective: To investigate the significance of 4 parameters of platelet and red cell defomation index(DI) in patients with diabetes meillitus (DM). Methods: The levels of mean platelet volume (MPV), plateletcrit (PCT), platelet distributionwide (PDW), platelet (PLT) and DI were measured with special analysor in 100 patients with DM. Eighty healthy volunteers served as controls. Results: Compared with the levels of controls, those of MPV, PCT and PDW were obviously higher and those of DI were lower, especially in the patients with micrangium lesens. There were a positive correlation between MPV and fasting blood-glucose (FPG) (r = 0.673, P<0.01) and a negative correlation between DI and FPG( r = -0.412,P<0.05). Conclusion: The micrangium lesens in patients with DM may be diagnosed, prevented and cured by monitoring the levels of MPV, PCT, PDW and DI.

关 键 词：糖尿病 毛细血管 血小板 红细胞 发病机理 

分 类 号：R587.102[医药卫生—内分泌]