炎性反应与急性冠脉事件发生的相关性研究  

The Relationship between Inflammation Reaction and Acute Coronary Events

作　　者：吴贤尧[1] 张春[1] 邱清芳[1] 杨敏娟[1] 

机构地区：[1]山东省莱州市人民医院,261400

出　　处：《医学理论与实践》2002年第3期259-261,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨炎性反应与急性冠脉事件之间的关系。方法:将1988年10月～2001年6月住院的急性冠脉事件患者分为3组:A组(急性心肌梗死),B组(不稳定型心绞痛),C组(健康组为对照)。检测其炎性反应敏感指标——MMP-9、CRP和体重指数、WBC、血糖、血脂(TC、TG)。结果:3组MMP-9升高者分别为45例(90％),35例(82.2％)和2例(5％),CRP升高者分别为41(82％),32例(71.1％)和3例(7.5％)。此二项3组间均有显著差异,其他各项的差异均无统计学意义。结论:MMP-9和CRP可作为急性冠脉事件的独立的预测指标。To explore the relationship between inflammatory response and acute coronary events. Methods: All of patients with acute coronary events were divided into three groups:patients with acute myocardial infarction( group A),patients with unstable angina pectoris(group B) and controlled group (group C) . Matrix metal proteinase-9(MMP-9) was measured using sandwich enzyme immunoassay and C-reactive protein ( CRP) was measured using immunonphelomytry. The following tests were done early during clinical visit and admission: blood pressure, BMI, WBC, fasting glucose, TC and TG. Results: The ratio of elevated baseline MMP-9 levels were 45/50,37/45 and 2/40, and that of CRP were 41/50,32/45,3/40, in group A, B and C, respectively. There were significant difference between group A, B and group C. Other markers did not reach statistical significance. Conclusion: As an inflammatory marker, MMP-9 or CRP was independent predictor of acute coronary events.

关 键 词：急性冠脉事件 炎性指标 基质金属蛋白酶-9 MMP-9 C反应蛋白 CRP 冠心病 

分 类 号：R541.402[医药卫生—心血管疾病]