克霉唑与氯冉酸的荷移反应及其测定  

Spectrophotometric Determination of Clotrimazole Based on Charge Transfer Reaction between Clotrimazole and Chloranilic Acid

作　　者：李华侃[1] 赵桂芝[1] 赵延清[1] 李佐[1] 

机构地区：[1]锦州医学院化学教研室,锦州121001

出　　处：《分析化学》2002年第3期334-336,共3页Chinese Journal of Analytical Chemistry

摘　　要：克霉唑与氯冉酸在丙酮介质中发生电荷转移反应 ,生成 1∶1型络合物 ,该络合物的λmax=5 2 5nm ,表观摩尔吸光系数是 1.2 2× 10 3 L·mol-1·cm-1,药物浓度在 0～ 30 0mg/L范围内符合比耳定律 ,6次测定的相对标准偏差为 1.4 % ,回收率在 97%以上。用拟定的方法测定药物片剂中有效成分的含量 。A spectrophotometric method for the determination of clotrimazole is described. The charge transfer reaction between clotrimazole and chloranilic acid takes place in acetone solution. The composition of the charge transfer complex is 1 : 1. Beer's law is obeyed in the range of 0 similar to 300 mg/L with correlation coefficient 0.9997. The apparent molar absorptivity is 1.22 x 10(3) L . mol(-1) . cm(-1) at 525 nm. The proposed method has been applied to determination of clotrimazole in tablets with satisfactory results.

关 键 词：电荷转移反应 克霉唑 氯冉酸 分光光度法 抗真菌药物 含量测定 片剂 

分 类 号：O657.3[理学—分析化学]