去脂软肝丸对四环素致小鼠脂肪肝模型肝脂的影响  

Effect of CZYGW on LTC and LTS in Fatty Liver Mice Caused by Tetracycline

作　　者：孙创斌[1] 淤泽溥[1] 林青[1] 张超[2] 李秀芳[1] 李立纪 

机构地区：[1]云南中医学院中药系,云南昆明650200 [2]云南省中医中药研究所,云南昆明650233 [3]昆明市医学科学研究所,云南昆明650011

出　　处：《云南中医学院学报》2002年第1期8-10,21,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：云南省科技厅自然科学基金资助项目

摘　　要：目的 :观察去脂软肝丸对四环素小鼠脂肪肝模型肝脂的影响。方法 :将小鼠随机分为 6组 ,各组分别给药 ,每日 1次 ,连续 11d。从第 8d起 ,除正常组外 ,各组小鼠均腹腔注射 2 3g/kg四环素 ,共 4d。末次给药后 1h ,处死小鼠 ,取肝组织 ,制肝匀浆 ,测肝TG、TC ,再取部分肝组织 ,做病理组织学检查。结果 :去脂软肝丸能明显降低由四环素所引起的小鼠肝TG。AIM: To observe the effect of CZYGW on LTG?LTC in fatty liver mice induced by tetracycline.METHOD:The experimental mice divided into 6 groups at random.Each group has been respectively treated with corresponding drugs for 11 days,once a day.Since the eighth day,mice have been ip administered with 2 3g/kg tetracycline for 4 days except the normal group.After an hour of the last treating,LTG?LTC were measured.Then take a part of liver organ,watch its pathologic tissue under a microscope.RESULT:CZYGW can obviously decrease the level of LTG?LTC in fatty liver mice induced by tetracycline.

关 键 词：去脂软肝丸 四环素 脂肪肝 血脂 肝脂 小鼠 中医药治疗 动物模型 

分 类 号：R259.755[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]