养阴通脑颗粒对脑缺血大鼠红细胞变形能力和小鼠减压缺氧耐力影响的实验研究  

Effects of Yangyin Tongnao Granules(YTG)on Red Cells Deformation Ablility of Rat with Cerebral lschemia and Mouse's Decompression Hypoxia Ability

作　　者：万海同 白海波[2] 黄绳武 余道军 别晓东[2] 

机构地区：[1]浙江中医学院,杭州310053 [2]浙江大学

出　　处：《浙江中医学院学报》2002年第2期44-46,共3页Journal of Zhejiang College of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(No.30070941) ;浙江省自然科学基金青年科技人才培养专项资金项目(No.RC00050)

摘　　要：目的 :探讨养阴通脑颗粒对脑缺血大鼠红细胞变形能力和小鼠减压缺氧耐力影响。方法 :采用四血管阻断法(4V0法)制作老年大鼠脑缺血损伤模型 ,观察养阴通脑颗粒对血液流变学指标的影响 ;采用小鼠减压缺氧耐力方法观察了本品的抗缺氧能力。结果 :养阴通脑颗粒具有提高红细胞变形能力、降低全血粘度的作用 ,延长减压缺氧小鼠存活时间。结论Objective:Explore the effects of YTG on red cells deformation ability of rat with cerebral ischemia and mouse's decompression hypoxia ability.Methods:Take 4 vascular blocking methods to make old rat's cerebral ischemia injury model,and observe the effect of YTG on the rheological indexes.Take mouse's decompression hypoxia tolerance method to observe the anti hypoxia of the medicine.Results:YTG can increase the red cell deformation ability,decrease the blood viscosity and prolong the survival time of the mouse with decompression hypoxia.Conclusion:YTG can improve the abnormal rheological changes of rat with cerebral ischemia and increase the mouse's hypoxia tolerance ability.

关 键 词：养阴通脑 全血粘度 减压缺氧耐力 中医药治疗 小鼠 脑缺血 大鼠 红细胞变形能力 

分 类 号：R277.733.1[医药卫生—中医学] R285.5