大疱性表皮松解型药疹16例临床分析  

Clinical analysis of 16 patients with bullous epidermolysis type of drug eruption

作　　者：黄淑琼[1] 王琳[2] 张敏[2] 周光平[2] 

机构地区：[1]乐山市人民医院皮肤科 [2]华西医科大学附属第一医院皮肤科,四川成都610041

出　　处：《皮肤病与性病》2002年第1期4-5,共2页Dermatology and Venereology

摘　　要：patients with bullous epidermolysis type of drug eruption over the last 8 years were studied,including 5 males and 11 females,aged 1 to 75 years old,Among them,there were 10 patients aged 20 to 30 years old,The main causative drugs included antibiotics,antipyretics,sulfonamides and hydrosulfides,All patients presented middle to high fever,loose bullae on skin,dermolysis and tenderness.More than 90% body surface were involved in 13 cases(81 25%),and mucosae were affected in 14 cases(87 5%).There were 10 patients(62 5%)converted from other types of drug eruption,and 4 combined with basal renal diseases,3 cases died at last.The reason of conversion,the key points of treatment and prognosis of thos disease were discussed.patients with bullous epidermolysis type of drug eruption over the last 8 years were studied,including 5 males and 11 females,aged 1 to 75 years old,Among them,there were 10 patients aged 20 to 30 years old,The main causative drugs included antibiotics,antipyretics,sulfonamides and hydrosulfides,All patients presented middle to high fever,loose bullae on skin,dermolysis and tenderness.More than 90% body surface were involved in 13 cases(81 25%),and mucosae were affected in 14 cases(87 5%).There were 10 patients(62 5%)converted from other types of drug eruption,and 4 combined with basal renal diseases,3 cases died at last.The reason of conversion,the key points of treatment and prognosis of thos disease were discussed.

关 键 词：大疱性表皮松解型药疹 TEN 致敏药物 临床表现 并发症 治疗 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]