系统性红斑狼疮患者血清IL-4和IFN-γ水平的测定及其临床意义  

The level and its significance of IL-4 and IFN-γ in the serum of patients with systemic lupus erythematosus

作　　者：王美美[1] 许桦[1] 许晋[1] 

机构地区：[1]东南大学附属中大医院风湿免疫科,南京210009

出　　处：《临床内科杂志》2002年第2期139-140,共2页Journal of Clinical Internal Medicine

摘　　要：目的　通过检测系统性红斑狼疮 (SLE)患者血清白细胞介素 4(IL 4)、γ 干扰素(IFN γ)的水平 ,探讨T淋巴细胞亚群与SLE发病的关系。方法　采用酶联免疫吸附法测定SLE患者和健康志愿者血清IL 4和IFN γ水平。结果　 (1)SLE活动组血清IL 4水平和IL 4/IFN γ比值明显升高 ,与非活动组和对照组比较 ,差异有非常显著性 (P <0 .0 0 1) ;(2 )血清IFN γ水平三组 (SLE活动组、非活动组和对照组 )比较 ,差异无显著性 (P >0 .0 5 ) ;(3 )SLE患者激素治疗后血清IL 4水平明显降低。结论　SLE患者血清IL 4水平和IL 4/IFN γ比值明显升高 ,且与病情活动性相关 ,IFN γ水平无明显变化 ,活动性SLE患者存在Th2细胞优势活化状态 。Objective To investigate the serum level of interleukin 4(IL 4,Th2 type cytokine) and interferon γ(IFN γ,Th1 type cytokine) in 45 patients with systemic lupus erythematosus(SLE) and 15 controls,and try to understand the role of Th1/Th2 balance in the pathogenesis of SLE.Methods Sandwich EIISA was used to measure the level of IL 4 and IFN γ in the serum of the patients and control group.Results The level of IL 4 and IL 4/IFN γratio in active stage were significantly higher than those in static phase and in control group (P<0.001).The IFN γ level was not statistically different between SLE patients and controld (P>0.05).The IL 4 dropped to very low level by steroid theropy.Conclusion The Th2 type cytokine(IL 4) was increased in active patients with SLE,and an imbalance towards Th2 predominance may play a significant role in the pathogenesis of SLE,regulating IL 4 level may provide a new approach for the treatment of SLE.

关 键 词：红斑狼疮 白细胞介素-4 Γ-干扰素 测定 系统性红斑狼疮 

分 类 号：R593.241[医药卫生—内科学]