联麦氧钒对糖尿病大鼠心肌脂蛋白脂酶mRNA表达的影响  

The effect of Bis (maltolato) oxovanadium (IV) on expression of LPL mRNA in cardiac myocytes of diabetic rats

作　　者：孔俭[1] 陈海艳[1] 王桂珍[1] 王秋利[2] 徐茂凤 

机构地区：[1]吉林大学第一临床医院干部病房,吉林长春130021 [2]吉林大学第四医院 [3]长春医学高等专科学校

出　　处：《中国老年学杂志》2002年第2期152-153,共2页Chinese Journal of Gerontology

基　　金：吉林省科技厅资助项目 (970 5582 )

摘　　要：目的　探讨糖尿病大鼠应用联麦氧钒 (BMOV)心肌脂蛋白脂酶 m RNA表达的变化规律。方法　采用逆转录聚合酶链式反应的方法。观察 BMOV治疗前后糖尿病大鼠心肌细胞脂蛋白脂酶 m RNA水平的变化。结果　糖尿病大鼠心肌脂蛋白脂酶 m RNA是升高的 ,经 BMOV治疗后心肌细胞脂蛋白脂酶 m RNA表达可降低 ,基本恢复到正常对照水平。结论　 BMOV可恢复糖尿病大鼠心肌细胞升高的脂蛋白脂酶 m RNA表达 ,调整脂代谢 ,改善心肌细胞能量物质的供给及利用。Objectives To explor the change of expression of LPL mRNA in cardiac myocytes of diabetic rats before and after BMOV treatment.Methods The levels of LPL mRNA in cardiac myocytes of diabetic rats before and after BMOV treatment were observed by RT-PCR.Results The levels of LPL mRNA in cardiac myocytes of diabetic group increased, but though BMOV treatment the levels of LPL mRNA decreased to control levels.Conclusions BMOV may ameliorate expression of LPL mRNA in cardiac myocytes of disbetic rats, adjust lipid metablisnm and improve the supply and ultillization of metabolic substrate.

关 键 词：钒化物 脂蛋白脂酶 糖尿病 逆转录聚合酶链式反应 MRNA表达 动物实验 

分 类 号：R587.1[医药卫生—内分泌]