诺氟沙星锌制备工艺研究  

Study on preparation process of norfioxacin zinc

作　　者：王淑清 孙湘丽 李晓云 周淑敏 

机构地区：[1]哈高科白天鹅药业有限责任公司,150070 [2]哈高科天健药业有限责任公司

出　　处：《黑龙江医药》2002年第2期95-97,共3页Heilongjiang Medicine journal

摘　　要：目的:确立诺氟沙星锌的化学合成工艺。方法:采用诺氟沙星与醋酸锌在碱性条件下加热合成并检测各项理化指标。结果:此工艺制得诺氟沙星锌含量为99.52±0.2353,PH值5.5～7.0。成品的收率95%以上。结论:制备工艺稳定可行。Objective:The chemical synthetic process of norfioxacin zinc has been established by the authors.Methods:norfioxacin zinc was synthesized from the starting material norfioxacin and zinc acid under the condition of NaOH and heating,and all physicochemical target were tested.Re- sult:Content 99.52+0.2353,PH5.5～7.0,the total yield of over 95%.Conclusion:The preparation process is stable and practicable.

关 键 词：诺氟沙星锌 合成 制备工艺 抗生素 诺氟沙星 醋酸锌 

分 类 号：TQ465[化学工程—制药化工]