卡介苗多糖核酸对慢性阻塞性肺疾病患者呼吸道感染的预防作用  

Preventive Effect of BCG-PSN on Respiratory Infection in Chronic Obstructive Pulmonary Disease

作　　者：张二明[1] 姚震[1] 向平超[1] 王于虹[1] 

机构地区：[1]北京首钢总医院,北京100041

出　　处：《中国医师杂志》2002年第2期154-155,共2页Journal of Chinese Physician

基　　金：国家"九五"重点攻关科技计划基金资助项目 (96 - 90 6 - 0 2 - 0 3)

摘　　要：目的　评价卡介苗多糖核酸对慢性阻塞性肺疾病 (COPD)患者呼吸道感染的预防作用。方法　 148例COPD患者随机分为预防组及对照组 ,预防组在一般治疗的基础上加用肌注卡介苗多糖核酸 0 5mg ,每周 2次 ,共 18次 ,对照组仅用一般治疗。两组患者每 2周门诊随访 1次 ,记录呼吸道感染次数、天数 ,于用药前、用药后 4周、2 4周查血清IgA、IgG、IgM ,共观察 6个月。结果　预防组呼吸道感染例数、感染天数及未发生感染率均明显低于对照组 (P <0 0 1)。结论　卡介苗多糖核酸对COPD患者有预防呼吸道感染的作用 ,减少复发次数 。Objective To evaluate the preventive effect of BCG-PSN on respiratory infection of patients with chronic obstructive pulmonary disease.Methods 48 cases with COPD were randomly divided into two groups:the BCG-PSN group and the control group.The BCG-PSN group received BCG-PSN,0 5mg,im,twice a week for 18 times injection in addition to the routine therapy,and the control group only received routine therapy.Both groups were followed up every two weeks for six months.The serum IgA,IgG,IgM levels were determined before and 4,24 weeks after the treatment.Results Cases of infection and their lasting days,infective rate in the BCG-PSN group were significantly lower than that of the control group(P<0 01).Conclusions BCG-PSN showed a preventive effect from respiratory infection in COPD,it could decrease respiratory infection recrudescence rate and severity.

关 键 词：卡介苗多糖核酸 肺疾病 呼吸道感染 预防 COPD 

分 类 号：R563.9[医药卫生—呼吸系统]